Molecular structure of β-Lapachone, CAS Number: 4707-32-8
β-Lapachone (CAS 4707-32-8)
See product citations (8)
Alternate Names:
3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione
Application:
β-Lapachone is a selective DNA topoisomerase I inhibitor
CAS Number:
4707-32-8
Purity:
≥98%
Molecular Weight:
242.27
Molecular Formula:
C15H14O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
β-Lapachone, a novel topoisomerase I (Topo I) inhibitor, does not stabilize the cleavable complex indicating a novel mode of action, unlike camptothecin (sc-200871). The compound exhibits the ability to induce apoptosis in various cell lines, such as prostate cancer and promyelocytic leukemia cells. It functions by blocking the cell cycle at the G0/G1 phase. Additionally, it exerts effects on DNA topoisomerase II, NF-κB, AP-1, and JNK signaling pathways.
β-Lapachone (CAS 4707-32-8) References
- beta-Lapachone-induced apoptosis is associated with activation of caspase-3 and inactivation of NF-kappaB in human colon cancer HCT-116 cells. | Choi, BT., et al. 2003. Anticancer Drugs. 14: 845-50. PMID: 14597880
- β-Lapachone ameliorization of experimental autoimmune encephalomyelitis. | Xu, J., et al. 2013. J Neuroimmunol. 254: 46-54. PMID: 23010281
- β-Lapachone enhances Mre11-Rad50-Nbs1 complex expression in cisplatin-induced nephrotoxicity. | Kim, TW., et al. 2016. Pharmacol Rep. 68: 27-31. PMID: 26721347
- β-lapachone and α-nor-lapachone modulate Candida albicans viability and virulence factors. | Moraes, DC., et al. 2018. J Mycol Med. 28: 314-319. PMID: 29598974
- β‑Lapachone ameliorates L‑DOPA‑induced dyskinesia in a 6‑OHDA‑induced mouse model of Parkinson's disease. | Ryu, YK., et al. 2021. Mol Med Rep. 23: PMID: 33495840
- Retracted: Inhibition of Nasopharyngeal Carcinoma by Beta-Lapachone Occurs by Targeting the Mammalian Target of Rapamycin (mTOR)/PI3K/AKT Pathway, Reactive Oxygen Species (ROS) Production, and Autophagy Induction. | Han, Y., et al. 2021. Med Sci Monit. 27: e931623. PMID: 33704260
- STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer. | Totten, SP., et al. 2021. Nat Commun. 12: 3299. PMID: 34083537
- The possibility of low isomerization of β-lapachone in the human body. | Lee, KM., et al. 2021. Transl Clin Pharmacol. 29: 160-170. PMID: 34621708
- β-lapachone: A Promising Anticancer Agent with a Unique NQO1 Specific Apoptosis in Pancreatic Cancer. | Qadir, MI., et al. 2022. Curr Cancer Drug Targets. 22: 537-540. PMID: 35490325
- A CRISPR screen identifies redox vulnerabilities for KEAP1/NRF2 mutant non-small cell lung cancer. | Jiang, C., et al. 2022. Redox Biol. 54: 102358. PMID: 35667246
- Synergistic Effect of β-Lapachone and Aminooxyacetic Acid on Central Metabolism in Breast Cancer. | Chang, MC., et al. 2022. Nutrients. 14: PMID: 35893874
- Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: a p53-independent response. | Planchon, SM., et al. 1995. Cancer Res. 55: 3706-11. PMID: 7641180
- beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. | Li, CJ., et al. 1993. J Biol Chem. 268: 22463-8. PMID: 8226754
Inhibitor of:
4930430F08Rik, 4930547C10Rik, ARL2, BC005561, CTPS, Cyclophilin D, DNA pol λ, DNA pol ν, EXOSC1, GEN1, KDEL ER Marker, KIAA0090, LMP7, LOC283143, LOC643770, LOC645553, MBOAT4, Mitochondrial Topo I, Myosin IXb, NQO1, OS-9, RFC, RFC3, SMUG1, SWAP, TEN1, THAP9, TMEM106B, Top3, Topo, Topo I, and Topo IIIβ.Activator of:
26S Proteasome p58, 4930547C10Rik, BAP29, BORIS, CDD, DDRGK1, DDX50, Edc4, FBXO31, FBXO4, GFR-1, GLB1L2, GLT8D4, GOLT1A, HERPUD2, LAP1B, LIMP II, MCFD2, REXO2, RNF13, RNF148, RNF175, SART-3, SENP5, TAF I p48, TFIIH p8, TMEM39A, TNRC6B, UGGT1, and YY1AP1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
β-Lapachone, 5 mg | sc-200875 | 5 mg | $110.00 | |||
| US: Only available in the US | ||||||
β-Lapachone, 25 mg | sc-200875A | 25 mg | $450.00 | |||
| US: Only available in the US | ||||||