LEF-1 Inhibitors
Common LEF-1 Inhibitors include, but are not limited to XAV939 CAS 284028-89-3, LGK 974 CAS 1243244-14-5, Wnt-C59 CAS 1243243-89-1, IWP-2 CAS 686770-61-6 and β-Catenin/Tcf Inhibitor, FH535 CAS 108409-83-2.
LEF-1 inhibitors belong to a distinct chemical class designed to selectively target and modulate the activity of the lymphoid enhancer-binding factor 1 (LEF-1), a transcription factor that plays a pivotal role in the Wnt signaling pathway. The Wnt signaling pathway is a complex network of molecular interactions that controls various aspects of cellular development, differentiation, proliferation, and homeostasis. LEF-1, along with its co-factor T-cell factor (TCF), acts as a key mediator in the canonical Wnt pathway by binding to Wnt-responsive DNA elements and facilitating the transcription of target genes.
These inhibitors are engineered to interact with the active site or binding domains of LEF-1, influencing its ability to interact with DNA and initiate gene transcription within the context of the Wnt signaling cascade. By targeting LEF-1 and disrupting its involvement in the Wnt pathway, insights into the molecular mechanisms underlying this critical cellular signaling process are gained. Investigating the effects of LEF-1 inhibitors in the context of the Wnt signaling pathway offers a deeper understanding of how this pathway regulates fundamental cellular functions and contributes to various biological processes. This knowledge can help unravel the complex interplay between Wnt signaling, gene expression, and cellular behavior, providing valuable information for advancing our understanding of developmental biology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
XAV939 is thought to inhibit the Wnt/β-catenin signaling pathway by promoting the degradation of the β-catenin protein through increasing its phosphorylation and preventing its interaction with key components of the destruction complex. This disruption of β-catenin stability results in decreased transcriptional activation of target genes. | ||||||
PRI-724 | 1422253-38-0 | sc-507535 | 25 mg | $255.00 | ||
PRI-724 is believed to work by disrupting the interaction between β-catenin and its coactivator CBP. This disruption hinders the transcriptional activation of Wnt target genes, leading to a reduction in Wnt signaling activity. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $352.00 $1270.00 | 2 | |
LGK-974 is a selective inhibitor of the Wnt signaling pathway that targets the Wnt acyltransferase Porcupine (PORCN), an enzyme essential for Wnt ligand secretion. Inhibition of PORCN reduces the secretion of Wnt ligands and consequently attenuates Wnt signaling. | ||||||
Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $210.00 $320.00 $1250.00 | 1 | |
C59 is a small molecule inhibitor of PORCN, the enzyme responsible for palmitoylation and secretion of Wnt ligands. Inhibition of PORCN by C59 leads to reduced Wnt ligand secretion and subsequent suppression of Wnt signaling. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
IWP-2 inhibits Wnt signaling by targeting the acyltransferase PORCN, which is responsible for the lipid modification and secretion of Wnt ligands. Inhibition of PORCN activity reduces the availability of active Wnt ligands for receptor binding and signal transduction. | ||||||
ETC-159 | 1638250-96-0 | sc-507415 | 5 mg | $90.00 | ||
ETC-159 is another PORCN inhibitor that hampers the lipid modification and secretion of Wnt ligands, effectively reducing their signaling activity and downstream transcriptional responses. | ||||||
NSC 668036 | 144678-63-7 | sc-507412 | 5 mg | $175.00 | ||
NSC 668036 is proposed to inhibit the Wnt/β-catenin pathway by directly targeting the TCF/LEF transcription factor. It disrupts the interaction between TCF/LEF and β-catenin, preventing the transcriptional activation of Wnt-responsive genes. | ||||||
β-Catenin/Tcf Inhibitor, FH535 | 108409-83-2 | sc-221398 sc-221398A | 10 mg 50 mg | $178.00 $367.00 | 7 | |
FH535 is thought to inhibit the Wnt/β-catenin pathway by blocking the interaction between β-catenin and TCF transcription factors. This interference disrupts the formation of the transcriptional complex necessary for Wnt target gene activation. | ||||||