LDHA Activators

Common LDHA Activators include, but are not limited to 2-Deoxy-D-glucose CAS 154-17-6, 1,1-Dimethylbiguanide, Hydrochloride CAS 1115-70-4, AICAR CAS 2627-69-2, Phenformin Hydrochloride CAS 834-28-6 and Rottlerin CAS 82-08-6.

LDHA activators are compounds that stimulate the activity or expression of lactate dehydrogenase A (LDHA). LDHA is one of the isoforms of lactate dehydrogenase, an enzyme that plays a pivotal role in the glycolytic pathway. Specifically, LDHA catalyzes the conversion of pyruvate to lactate, coupled with the interconversion of NADH to NAD+. This reaction is particularly significant in tissues and conditions where the oxygen supply is limited, leading to anaerobic glycolysis as the primary source of ATP.

The significance of LDHA extends beyond its metabolic role. Given its involvement in glycolysis, it plays a key part in the Warburg effect, a phenomenon observed in many proliferative cells, especially cancer cells, where there's a preference for glycolysis even in the presence of adequate oxygen – a deviation from the typical reliance on oxidative phosphorylation in most normal cells. LDHA activators, by enhancing the enzyme's activity or expression, can amplify the glycolytic flux, influencing the cellular energy balance and redox state. Understanding the mechanisms and implications of LDHA activation provides critical insights into the metabolic adjustments cells make under different physiological conditions. Delving into the realm of LDHA activators emphasizes the enzyme's central role in modulating cellular energy dynamics, especially in scenarios demanding rapid ATP production. The modulation of LDHA activity offers a window into the broader landscape of cellular metabolism, highlighting the intricate balance between glycolysis and oxidative phosphorylation, and underscoring the adaptability of cells to fluctuating environmental conditions and energy demands.