Date published: 2026-1-11

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LAT2 Inhibitors

The chemicals listed above are not direct inhibitors of LAT2 but can potentially influence its activity or expression through various signaling pathways and cellular processes in T cells and natural killer cells. LAT2 is involved in the intracellular signaling cascades that follow T cell receptor (TCR) engagement, playing a role in the immune response. Immunosuppressive agents like Cyclosporine A and FK506 (Tacrolimus) inhibit calcineurin, a critical enzyme in T cell activation. By modulating T cell activation, these compounds could indirectly affect LAT2 signaling, as LAT2 is involved in the downstream signaling of activated T cells. Sirolimus (Rapamycin) targets the mTOR pathway, which is important in T cell metabolism and function. By influencing this pathway, Rapamycin could have an indirect effect on LAT2-mediated signaling.

Tyrosine kinase inhibitors such as Dasatinib, Nilotinib, and Ibrutinib can impact various aspects of T cell signaling. Since LAT2 is associated with tyrosine phosphorylation events in T cells, these inhibitors might indirectly modify LAT2 activity. Idelalisib, a PI3K inhibitor, and Sotrastaurin, a protein kinase C inhibitor, target other key enzymes in T cell signaling pathways. Their modulation of these pathways could potentially influence LAT2 signaling. Immunomodulatory drugs like Lenalidomide and Thalidomide alter the immune response, which could indirectly affect LAT2 activity in lymphocytes.Bortezomib, a proteasome inhibitor, and Venetoclax, a BCL-2 inhibitor, can influence cell survival and activation in immune cells, potentially impacting LAT2 signaling pathways.

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Items 1 to 10 of 12 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Cyclosporin A

59865-13-3sc-3503
sc-3503-CW
sc-3503A
sc-3503B
sc-3503C
sc-3503D
100 mg
100 mg
500 mg
10 g
25 g
100 g
$63.00
$92.00
$250.00
$485.00
$1035.00
$2141.00
69
(5)

Inhibits calcineurin, indirectly affecting T cell activation and potentially LAT2 signaling.

FK-506

104987-11-3sc-24649
sc-24649A
5 mg
10 mg
$78.00
$151.00
9
(1)

A calcineurin inhibitor, which can indirectly influence LAT2 by modulating T cell activation.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

An mTOR inhibitor, potentially affecting T cell signaling pathways involving LAT2.

Dasatinib

302962-49-8sc-358114
sc-358114A
25 mg
1 g
$70.00
$145.00
51
(1)

A tyrosine kinase inhibitor, which may indirectly influence LAT2 signaling in T cells.

Ibrutinib

936563-96-1sc-483194
10 mg
$156.00
5
(0)

Inhibits Bruton's tyrosine kinase, potentially impacting signaling pathways related to LAT2.

CAL-101

870281-82-6sc-364453
10 mg
$193.00
4
(1)

A PI3K inhibitor, which could indirectly affect LAT2 signaling in lymphocytes.

Nilotinib

641571-10-0sc-202245
sc-202245A
10 mg
25 mg
$209.00
$413.00
9
(1)

A tyrosine kinase inhibitor, potentially influencing LAT2 indirectly through T cell signaling.

Sotrastaurin

425637-18-9sc-474229
sc-474229A
5 mg
10 mg
$300.00
$540.00
(0)

Inhibits protein kinase C, potentially affecting T cell activation and LAT2 signaling.

Lenalidomide

191732-72-6sc-218656
sc-218656A
sc-218656B
10 mg
100 mg
1 g
$50.00
$374.00
$2071.00
18
(1)

Modulates immune response and might indirectly influence LAT2 activity.

Thalidomide

50-35-1sc-201445
sc-201445A
100 mg
500 mg
$111.00
$357.00
8
(0)

Alters immune cell signaling, potentially impacting LAT2 signaling pathways.