LASS3 Inhibitors

LASS3 inhibitors are a class of chemicals that are primarily geared towards influencing the function of the LASS3 protein. As LASS3 plays a significant role in ceramide synthesis, a pivotal aspect of sphingolipid metabolism, most inhibitors target various facets of this pathway. Fumonisin B1, for instance, acts by inhibiting ceramide synthase, directly impacting the enzyme family to which LASS3 belongs. On the other hand, compounds like Myriocin target earlier steps in the sphingolipid biosynthesis pathway, indirectly affecting LASS3's role in ceramide production.

Another strategy involves modulating ceramide levels through feedback mechanisms. Desipramine and Ceranib-2 inhibit ceramidases leading to ceramide accumulation, which can then exert feedback control on LASS3 activity. Similarly, compounds like PDMP focus on the downstream process, inhibiting glucosylceramide synthase and thus impacting glycosphingolipid synthesis. This alteration in ceramide pools can modulate LASS3's synthesis activity.