Molecular structure of Desipramine hydrochloride, CAS Number: 58-28-6
Desipramine hydrochloride (CAS 58-28-6)
See product citations (6)
Alternate Names:
N-(gamma-Methylaminopropyl)iminodibenzyl hydrochloride
Application:
Desipramine hydrochloride is an inhibitor of norepinephrine, serotonin, and dopamine transporters
CAS Number:
58-28-6
Purity:
≥98%
Molecular Weight:
302.84
Molecular Formula:
C18H22N2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Desipramine hydrochloride is a selective inhibitor of noradrenaline transporters norepinephrine transporter (SLC6A2 or NET Ki = 4 nM), serotonin transporter (ST or SERT Ki = 61 nM), and dopamine transporter (DAT Ki = 78,720 nM). This compound is a potent inhibitor of the norepinephrine transporter, and also blocks serotonin re-uptake. This compound has also been shown to reverse the pro-apoptotic effect of chronic unpredictable mild stress in the rat cerebral cortex, although it induces apoptosis in several cancer cell lines. It has also been shown to display anti-inflammatory activity in a rat colitis model.
Desipramine hydrochloride (CAS 58-28-6) References
- Long-term treatment with antidepressants increases glucocorticoid receptor binding and gene expression in cultured rat hippocampal neurones. | Okugawa, G., et al. 1999. J Neuroendocrinol. 11: 887-95. PMID: 10520140
- LLC-PK(1) cells stably expressing the human norepinephrine transporter: A functional model of carrier-mediated norepinephrine release in protracted myocardial ischemia. | Smith, NC. and Levi, R. 1999. J Pharmacol Exp Ther. 291: 456-63. PMID: 10525059
- Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. | Zhao, Z., et al. 2008. Neuropsychopharmacology. 33: 3190-200. PMID: 18418364
- Chronic unpredictable stress promotes neuronal apoptosis in the cerebral cortex. | Bachis, A., et al. 2008. Neurosci Lett. 442: 104-8. PMID: 18621098
- A reconstructed human epidermal keratinization culture model to characterize ceramide metabolism in the stratum corneum. | Yoshida, N., et al. 2012. Arch Dermatol Res. 304: 563-77. PMID: 22451348
- Monitoring the Prevalence of Leucocytozoon sabrazesi in Southern China and Testing Tricyclic Compounds against Gametocytes. | Zhao, W., et al. 2016. PLoS One. 11: e0161869. PMID: 27571513
- A pilot study of the mechanism of action of desipramine. | Checkley, SA., et al. 1981. Br J Psychiatry. 138: 248-51. PMID: 6268238
- Crossover study of zimelidine and desipramine in depression: evidence for amine specificity [proceedings]. | Potter, WZ., et al. 1981. Psychopharmacol Bull. 17: 26-9. PMID: 6453356
- Down-regulation of the human norepinephrine transporter in intact 293-hNET cells exposed to desipramine. | Zhu, MY., et al. 1998. J Neurochem. 70: 1547-55. PMID: 9523572
Inhibitor of:
ASAH3L, CCZ1, Ceramide Synthase (CERS; LASS), CERKL, DAT, DGS8, EG666955, GLTPD1, HS3ST4, LAL, LASS1, LASS2, LASS3, neutral ceramidase, Olfr952, Olfr957, Olfr963, ORMDL2, saposin, SLC6A2, SMPDL3A, SMPDL3B, ST, SULT1C4, SULT2A6, SULT2A7, SULT6B1, TREK-1, UST, and VPS37.Activator of:
ASAH2C, FAN, LASS2, Lyst, PSAPL1, and TMEM175.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Desipramine hydrochloride, 100 mg | sc-200158 | 100 mg | $66.00 | |||
Desipramine hydrochloride, 1 g | sc-200158A | 1 g | $117.00 |