LASS3 Activators
Ceramide synthase 3 activators constitute a class of compounds that interact with various facets of the sphingolipid metabolism pathway, primarily affecting the balance of ceramide and its related lipids within cells. These activators either provide substrate for ceramide synthesis, modulate the gene expression of enzymes within the pathway, or perturb the sphingolipid metabolic flux, thereby indirectly influencing the activity of LASS3. While no direct chemical agonists for LASS3 are known, substrate availability, such as sphingosine, palmitoyl-CoA, and sphinganine, serve as activators by being converted into ceramides through the enzymatic action of LASS3. Compounds that induce stress responses or modulate other steps in the sphingolipid pathway, like Fumonisin B1 or Myriocin, might increase LASS3 activity through compensatory cellular responses aimed at restoring lipid homeostasis.
Conversely, molecules that upregulate the expression of LASS3, such as Vitamin D3 and retinoic acid, can increase the amount of active enzyme present, hence elevating ceramide synthesis capacity. Adjustments in the expression and activity of related enzymes and pathways by SRT1720, a SIRT1 activator, illustrate indirect means through which LASS3 activity can be modulated. The manipulation of ceramide levels, either by breaking down complex sphingolipids or by introducing synthetic ceramide analogs, can also result in the upregulation of LASS3 activity as a feedback mechanism.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P can act as a secondary messenger and influence ceramide synthesis by feedback regulation. An increase in S1P levels can lead to the activation of LASS3 as part of a compensatory mechanism to balance the levels of sphingolipids within the cell. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 has been shown to upregulate the expression of LASS3, thus potentially increasing the activity of LASS3 by elevating the amount of the enzyme available to synthesize ceramides. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can modulate gene expression and might upregulate LASS3 expression, thereby increasing the activity of LASS3 and enhancing ceramide synthesis. | ||||||
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $90.00 $194.00 $510.00 $2448.00 $9384.00 $15300.00 | 2 | |
As a sphingolipid base, D-erythro-Sphingosine serves as a substrate for LASS3. Providing more of this substrate can activate LASS3 by enabling more frequent catalysis of ceramide synthesis. | ||||||
2-Fluoro-3-methoxyphenylboronic acid | 352303-67-4 | sc-254237 | 1 g | $39.00 | ||
Synthetic analogs of ceramide like C2-ceramide can increase cellular ceramide levels and may indirectly enhance LASS3 activity through feedback mechanisms within the sphingolipid biosynthesis pathway. | ||||||
Phytosphingosine | 554-62-1 | sc-201385 sc-201385A | 5 mg 25 mg | $102.00 $427.00 | 4 | |
This sphingoid base can act as a substrate for LASS3, potentially activating the enzyme to synthesize complex sphingolipids. | ||||||
4-Hydroxyphenylretinamide | 65646-68-6 | sc-200900 sc-200900A | 5 mg 25 mg | $104.00 $315.00 | ||
A synthetic retinoid that can induce apoptosis via the ceramide pathway, possibly resulting in increased LASS3 activity to elevate ceramide levels as part of the apoptotic signaling process. | ||||||
SRT1720 | 1001645-58-4 | sc-364624 sc-364624A | 5 mg 10 mg | $197.00 $364.00 | 13 | |
A SIRT1 activator, which has been shown to affect sphingolipid metabolism; increased SIRT1 activity can modulate the function of proteins involved in lipid metabolism, potentially leading to upregulation of LASS3 activity. | ||||||