Molecular structure of SKI II, CAS Number: 312636-16-1
SKI II (CAS 312636-16-1)
See product citations (3)
Alternate Names:
Sphingosine Kinase Inhibitor 2; 4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
Application:
SKI II is a non-lipid inhibitor of sphingosine kinase
CAS Number:
312636-16-1
Purity:
≥95%
Molecular Weight:
302.78
Molecular Formula:
C15H11ClN2OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SKI II is a selective non-lipid inhibitor of SphK(sphingosine kinase) (IC50 = 0.5 µM) does not act at ATP-binding site. SKI II displays no inhibition of ERK2, PI 3-kinase, or PKCalpha at concentrations up to 60 muM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. SKI II induces apoptosis and inhibits prpliferation in several other tumor cell lines in vitro (IC50 = 0.9-4.6 muM).
SKI II (CAS 312636-16-1) References
- A novel mode of action of the putative sphingosine kinase inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole (SKI II): induction of lysosomal sphingosine kinase 1 degradation. | Ren, S., et al. 2010. Cell Physiol Biochem. 26: 97-104. PMID: 20502009
- SKI-II, an inhibitor of sphingosine kinase, ameliorates antigen-induced bronchial smooth muscle hyperresponsiveness, but not airway inflammation, in mice. | Chiba, Y., et al. 2010. J Pharmacol Sci. 114: 304-10. PMID: 20948165
- Reversion of multidrug resistance by SKI-II in SGC7901/DDP cells and exploration of underlying mechanisms. | Zhu, ZA., et al. 2012. Asian Pac J Cancer Prev. 13: 625-31. PMID: 22524836
- The blockage of Ras/ERK pathway augments the sensitivity of SphK1 inhibitor SKI II in human hepatoma HepG2 cells. | Zhang, C., et al. 2013. Biochem Biophys Res Commun. 434: 35-41. PMID: 23545258
- Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers. | Mercado, N., et al. 2014. PLoS One. 9: e88168. PMID: 24505412
- Inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II. | Cingolani, F., et al. 2014. J Lipid Res. 55: 1711-20. PMID: 24875537
- SKI-II reverses the chemoresistance of SGC7901/DDP gastric cancer cells. | Liu, Y., et al. 2014. Oncol Lett. 8: 367-373. PMID: 24959278
- A sphingosine kinase-1 inhibitor, SKI-II, induces growth inhibition and apoptosis in human gastric cancer cells. | Li, PH., et al. 2014. Asian Pac J Cancer Prev. 15: 10381-5. PMID: 25556479
- SKI-II--a sphingosine kinase 1 inhibitor--exacerbates atherosclerosis in low-density lipoprotein receptor-deficient (LDL-R-/-) mice on high cholesterol diet. | Potì, F., et al. 2015. Atherosclerosis. 240: 212-5. PMID: 25801013
- SphK1 inhibitor II (SKI-II) inhibits acute myelogenous leukemia cell growth in vitro and in vivo. | Yang, L., et al. 2015. Biochem Biophys Res Commun. 460: 903-8. PMID: 25824043
- From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II). | Aurelio, L., et al. 2016. J Med Chem. 59: 965-84. PMID: 26780304
- SphK1 inhibitor SKI II inhibits the proliferation of human hepatoma HepG2 cells via the Wnt5A/β-catenin signaling pathway. | Liu, H., et al. 2016. Life Sci. 151: 23-29. PMID: 26944438
- Dual sphingosine kinase inhibitor SKI-II enhances sensitivity to 5-fluorouracil in hepatocellular carcinoma cells via suppression of osteopontin and FAK/IGF-1R signalling. | Grbčić, P., et al. 2017. Biochem Biophys Res Commun. 487: 782-788. PMID: 28433634
- Sphingosine kinase inhibitor, SKI-II confers protection against the ionizing radiation by maintaining redox homeostasis most likely through Nrf2 signaling. | Sah, DK., et al. 2021. Life Sci. 278: 119543. PMID: 33933460
- The Sphingolipid Inhibitors Ceranib-2 and SKI-II Reduce Measles Virus Replication in Primary Human Lymphocytes: Effects on mTORC1 Downstream Signaling. | Chithelen, J., et al. 2022. Front Physiol. 13: 856143. PMID: 35370781
Inhibitor of:
APHC, ASAH2B, Ceramide Synthase (CERS; LASS), ephrin-A5, LASS3, MFSD2B, neutral ceramidase, ORMDL2, PAP-2b, SMPD5, SMS2, SO, Sphingomyelin Synthase 1, SphK, SphK1, SphK2, and SPHKAP.Activator of:
EVT-2, iGb3, MTMR15, O-Ac GD3, SK2, and SPNS1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SKI II, 10 mg | sc-204286 | 10 mg | $94.00 | |||
SKI II, 50 mg | sc-204286A | 50 mg | $392.00 |