LARP2 Inhibitors
LARP2 inhibitors encompass a variety of chemical compounds that indirectly influence the functional activity of this protein through multiple signaling pathways. Rapamycin, LY294002, and Wortmannin act on the PI3K/AKT/mTOR axis, which is crucial for mRNA translation. By inhibiting mTOR, these compounds can suppress the synthesis of LARP2 by diminishing translation initiation. Concurrently, U0126 and PD98059 target MEK1/2 in the MAPK pathway, potentially affecting the synthesis of LARP2 if it is regulated by ERK-mediated signaling. Similarly, SB203580 disrupts p38 MAPK signaling, which could affect the stability or translation of LARP2. These inhibitors demonstrate how indirect modulation of upstream pathways can lead to a decrease in LARP2's functional activity.
In addition to these inhibitors, other compounds such as Spautin-1, Dasatinib, SH-4-54, MLN4924, Alisertib, and Bortezomib contribute to LARP2 inhibition through diverse mechanisms. Spautin-1, by inhibiting autophagy, could increase the stability of proteins that negatively regulate LARP2, while Dasatinib and SH-4-54 can perturb Src and STAT family signaling, respectively, potentially reducing the expression or activity of LARP2. MLN4924 affects protein degradation pathways, possibly altering the regulation of LARP2 activity. Alisertib interferes with cell cycle progression, which may impact the translation orstability of LARP2. Lastly, Bortezomib, a proteasome inhibitor, leads to the accumulation of proteins that downregulate or degrade LARP2, thereby decreasing its activity. Each of these inhibitors, by acting on different molecular targets and pathways, collectively contributes to the inhibition of LARP2, highlighting the complex network of cellular signaling that dictates its function.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that can suppress the mTOR pathway, which is crucial for the translation of mRNA into proteins. Inhibition of mTOR by rapamycin could decrease the synthesis of LARP2 due to reduced translation initiation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that disrupts the PI3K/AKT/mTOR signaling cascade. By inhibiting this pathway, LY294002 can lead to reduced mTOR activity, which in turn may result in decreased synthesis of LARP2 due to lower translational capacity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that can attenuate the PI3K/AKT/mTOR pathway. Its action can lead to reduced translation initiation, potentially diminishing the synthesis and activity of LARP2. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are upstream of ERK in the MAPK pathway. By inhibiting this pathway, U0126 could indirectly affect the synthesis of proteins like LARP2 that may be regulated by ERK-mediated signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK1/2, thus disrupting ERK pathway signaling. This can indirectly result in reduced expression or activity of LARP2 if its expression is ERK-dependent. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $165.00 | ||
Spautin-1 is a selective autophagy inhibitor that targets the degradation of ubiquitinated proteins. By inhibiting autophagy, Spautin-1 could potentially stabilize the turnover of proteins that negatively regulate LARP2, leading to its decreased activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that may indirectly influence the stability or translation of LARP2 through inhibition of p38 MAPK-dependent signaling pathways. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a Src family kinase inhibitor that could affect multiple signaling pathways, including those that might regulate the synthesis or function of LARP2. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
MLN4924 is a NEDD8-activating enzyme inhibitor that can affect protein degradation pathways. Inhibition of this enzyme could alter the degradation rate of regulatory proteins that control LARP2 expression or function. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
Alisertib is an Aurora kinase A inhibitor that can disrupt cell cycle progression and may influence the translation or stability of proteins such as LARP2. | ||||||