LANCL3 Activators
The functional activity of LANCL3 can be modulated through a variety of signaling pathways influenced by specific chemical activators. These activators function through different mechanisms, each converging on the modulation of LANCL3 activity. For instance, certain compounds can directly stimulate adenylate cyclase, leading to a rise in intracellular cAMP levels, which in turn may result in the activation of LANCL3 through a PKA-dependent mechanism. Similarly, other activators work by releasing nitric oxide, subsequently activating guanylate cyclase and increasing cGMP levels, providing another route through which LANCL3 activation may be achieved. Additionally, some activators influence intracellular calcium levels, either directly or via G protein-coupled receptors, which can activate calcium-dependent protein kinases, potentially culminating in the phosphorylation and subsequent activation of LANCL3.
Furthermore, there are activators that work by modulating the cellular concentrations of second messengers, either by preventing their breakdown or by facilitating their buildup through different modes of action. For example, the inhibition of phosphodiesterases or the provision of cell-permeable analogs of signaling molecules can lead to sustained activation of cAMP- or cGMP-dependent pathways, indirectly elevating LANCL3 activity. Other chemical activators may increase the activity of various protein kinases and phosphatases, thereby altering the phosphorylation state of target proteins including LANCL3. Additionally, certain polyphenolic compounds can activate key regulators of cellular metabolism and protein function, such as sirtuins and AMPK, which may in turn influence LANCL3 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C (PKC) which can phosphorylate proteins downstream, potentially including LANCL3, thereby enhancing LANCL3 activity through modulation of protein-protein interactions and signaling cascades. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Increases intracellular calcium levels, which could activate calcium-dependent protein kinases that may phosphorylate and activate LANCL3, linking intracellular calcium signaling to LANCL3 activity. | ||||||
(±)-S-Nitroso-N-acetylpenicillamine | 79032-48-7 | sc-200319B sc-200319 sc-200319A | 10 mg 20 mg 100 mg | $74.00 $114.00 $374.00 | 18 | |
Donates nitric oxide which can lead to the activation of guanylate cyclase, increasing cGMP levels. Elevated cGMP could enhance LANCL3 activity by cGMP-dependent protein kinases or other cGMP-mediated signaling mechanisms. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Non-specific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP, thereby potentially enhancing LANCL3 activity due to increased levels of these signaling molecules. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Increases intracellular zinc concentration, which can act as a second messenger in several signaling pathways. This elevation might activate LANCL3 directly or through the modulation of zinc-sensitive kinases or phosphatases. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A polyphenol that may modulate various protein kinases and phosphatases, potentially altering phosphorylation states and activities of target proteins including LANCL3, thereby indirectly increasing its functional activity. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
Binds to its G protein-coupled receptors (GPCRs) initiating downstream signaling that can culminate in the activation of various kinases, possibly leading to the phosphorylation and activation of LANCL3. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $43.00 $85.00 $158.00 | 7 | |
Releases nitric oxide which activates guanylate cyclase and raises cGMP levels. This cascade can lead to the activation of LANCL3 through cGMP-dependent kinases or signaling pathways. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Acts as a signaling molecule that can modulate the activity of phosphatases and kinases. This modulation could result in the altered phosphorylation state of LANCL3, thus influencing its functional activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
A cell-permeable cAMP analog that directly activates cAMP-dependent pathways, potentially leading to enhanced phosphorylation and activation of LANCL3. | ||||||