Laminin-5 Inhibitors
Laminin-5 Inhibitors encompass a diverse range of compounds capable of directly or indirectly modulating Laminin-5, a critical extracellular matrix protein involved in cellular adhesion and migration. Among these inhibitors, the dynamics of the cytoskeleton play a central role in regulating Laminin-5 function. Colchicine, a microtubule disruptor, indirectly inhibits Laminin-5 by perturbing the cellular microenvironment necessary for proper cytoskeletal dynamics, which is crucial for Laminin-5 localization. In addition to cytoskeletal modulators, inhibitors such as Wortmannin and LY294002 target the phosphoinositide 3-kinase (PI3K) pathway. These compounds indirectly inhibit Laminin-5 by disrupting signaling cascades associated with cellular processes critical for its proper function. Another indirect inhibitor, Blebbistatin, impacts actomyosin contractility, influencing the dynamic regulation of the actin cytoskeleton, and subsequently hindering Laminin-5 functionality.
Furthermore, the class includes inhibitors like Rapamycin and SB431542, which target mTOR and TGF-β signaling pathways, respectively. These compounds act indirectly by modulating pathways that influence the expression or activity of Laminin-5, thus affecting its role in cellular adhesion and migration. Actin cytoskeleton modulators such as Jasplakinolide and Latrunculin A disrupt Laminin-5 indirectly by perturbing the dynamics of the actin cytoskeleton, essential for proper Laminin-5 function. In summary, Laminin-5 Inhibitors offer a comprehensive understanding of the intricate mechanisms through which a variety of chemicals can influence Laminin-5. The indirect inhibition involves disruption of signaling pathways or cellular processes critical for Laminin-5 expression or activity, highlighting the complexity of cellular responses associated with the modulation of this extracellular matrix protein.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine disrupts microtubule polymerization, impacting cellular processes associated with cytoskeletal dynamics. Laminin-5, an extracellular matrix protein, relies on intact cytoskeletal structures for proper localization and function, making colchicine an indirect inhibitor by disrupting the cellular microenvironment necessary for Laminin-5 function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
An inhibitor of phosphoinositide 3-kinase (PI3K), Wortmannin disrupts downstream signaling pathways. Since PI3K is involved in cellular processes related to Laminin-5, Wortmannin can act as an indirect inhibitor by modulating pathways that influence the expression or activity of Laminin-5. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Blebbistatin inhibits myosin II ATPase activity, impacting actomyosin contractility. Laminin-5 localization and function depend on the dynamic regulation of the actin cytoskeleton. Therefore, Blebbistatin can act as an indirect inhibitor by disrupting actomyosin dynamics critical for proper Laminin-5 function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A phosphoinositide 3-kinase (PI3K) inhibitor, LY294002 disrupts signaling cascades associated with cellular processes linked to Laminin-5. Its indirect inhibitory action involves modulation of pathways influencing the expression or activity of Laminin-5, altering its role in cellular adhesion and migration. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D disrupts actin polymerization, influencing the integrity of the cytoskeleton. Given that Laminin-5 relies on an intact cytoskeleton for proper localization and function, Cytochalasin D acts as an indirect inhibitor by perturbing the cellular microenvironment necessary for Laminin-5 functionality. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor, Rapamycin disrupts pathways involved in cellular processes linked to Laminin-5. Its indirect inhibitory action modulates signaling cascades, influencing the expression or activity of Laminin-5 and thereby impacting its role in cellular adhesion and migration. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $270.00 | 5 | |
Bleomycin induces DNA damage and triggers apoptosis, affecting cellular processes associated with Laminin-5. Its indirect inhibitory action involves the modulation of pathways influencing Laminin-5 expression or activity, impacting its role in cellular adhesion and migration. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
A selective inhibitor of TGF-β type I receptor (ALK5), SB431542 disrupts TGF-β signaling pathways. Since TGF-β can influence cellular processes linked to Laminin-5, SB431542 can act as an indirect inhibitor by modulating pathways that affect the expression or activity of Laminin-5. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
An actin polymerization inducer, Jasplakinolide impacts the dynamics of the actin cytoskeleton. Laminin-5 localization and function depend on the proper regulation of the actin cytoskeleton. Therefore, Jasplakinolide acts as an indirect inhibitor by influencing actin dynamics critical for proper Laminin-5 function. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
A cell-permeable calcium chelator, BAPTA-AM disrupts calcium-dependent signaling cascades involved in cellular processes linked to Laminin-5. Its indirect inhibitory action modulates pathways influencing the expression or activity of Laminin-5, altering its role in cellular adhesion and migration. | ||||||