L2HGDH Activators
Activators that affect the functionality of L2HGDH, a mitochondrial enzyme, work through complex molecular interactions. L2HGDH's activity is intricately linked to the redox balance within the mitochondria and the overall energy metabolism of the cell. For example, changes in intracellular signaling molecules can result in modifications to the enzyme's phosphorylation state, potentially leading to an upregulation of its activity. The presence and balance of necessary coenzymes and substrates involved in critical metabolic cycles are vital for the L2HGDH's action. Supplying the right electron acceptors is crucial, as these are necessary for the enzyme to carry out its oxidative reactions. Additionally, an increase in the availability of specific metabolic cycle components through external sources might aid in the enzyme's processing functions, thereby boosting its activity. Compounds that support the mitochondrial electron transport system may also create an optimal environment for the enzyme's function, leading to an indirect enhancement of its activity.
Moreover, L2HGDH can be affected by alterations in its methylation status, with certain methyl donors potentially increasing its stability or catalytic efficiency. Introducing compounds that influence the redox state within the mitochondria may also have a stimulating effect on the enzyme. The synthesis of coenzymes necessary for the enzyme's reactions can be supported by the provision of specific vitamins, which in turn can enhance the enzyme's performance in its respective metabolic pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
Acts as a methyl donor in various reactions, potentially increasing stability or activity of L2HGDH through methylation of specific residues. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
As a coenzyme for dehydrogenases, NAD+ is essential for L2HGDH functionality, providing the necessary electron acceptor role for the oxidative dehydrogenation reaction catalyzed by L2HGDH. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Supports mitochondrial electron transport chain, which could enhance the redox state and indirectly augment L2HGDH activity by optimizing the mitochondrial environment. | ||||||
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $33.00 $43.00 $63.00 $110.00 $188.00 $738.00 $2091.00 | 2 | |
As part of the Krebs cycle, it may increase substrate availability for L2HGDH, facilitating its catalytic activity in the conversion of L-2-hydroxyglutarate to alpha-ketoglutarate. | ||||||
Succinic acid | 110-15-6 | sc-212961B sc-212961 sc-212961A | 25 g 500 g 1 kg | $45.00 $75.00 $133.00 | ||
As a Krebs cycle intermediate, it could enhance L2HGDH activity by influencing the cellular metabolic status and indirectly increasing the turnover of related metabolites. | ||||||
Methylene blue | 61-73-4 | sc-215381B sc-215381 sc-215381A | 25 g 100 g 500 g | $43.00 $104.00 $328.00 | 3 | |
Acts as an artificial electron acceptor which could indirectly stimulate L2HGDH activity by influencing the redox balance within the mitochondria. | ||||||
Pyruvic acid | 127-17-3 | sc-208191 sc-208191A | 25 g 100 g | $41.00 $96.00 | ||
As it enters the Krebs cycle, could enhance the flux of intermediates, potentially increasing the substrate availability for L2HGDH. | ||||||
Fumaric acid | 110-17-8 | sc-250031 sc-250031A sc-250031B sc-250031C | 25 g 100 g 500 g 2.5 kg | $43.00 $57.00 $114.00 $228.00 | ||
As a Krebs cycle intermediate, might indirectly enhance L2HGDH activity through metabolic flux adjustments. | ||||||
Malic acid | 6915-15-7 | sc-257687 | 100 g | $130.00 | 2 | |
Enhances the malate-aspartate shuttle, which could indirectly increase L2HGDH activity by improving NADH recycling in the mitochondria and thus the availability of NAD+. | ||||||
Riboflavin | 83-88-5 | sc-205906 sc-205906A sc-205906B | 25 g 100 g 1 kg | $41.00 $112.00 $525.00 | 3 | |
As a precursor of FAD, riboflavin supplementation might indirectly enhance L2HGDH activity as FAD-dependent enzymes play a role in the Krebs cycle and related metabolic pathways. | ||||||