Date published: 2026-2-14

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L2HGDH Activators

Activators that affect the functionality of L2HGDH, a mitochondrial enzyme, work through complex molecular interactions. L2HGDH's activity is intricately linked to the redox balance within the mitochondria and the overall energy metabolism of the cell. For example, changes in intracellular signaling molecules can result in modifications to the enzyme's phosphorylation state, potentially leading to an upregulation of its activity. The presence and balance of necessary coenzymes and substrates involved in critical metabolic cycles are vital for the L2HGDH's action. Supplying the right electron acceptors is crucial, as these are necessary for the enzyme to carry out its oxidative reactions. Additionally, an increase in the availability of specific metabolic cycle components through external sources might aid in the enzyme's processing functions, thereby boosting its activity. Compounds that support the mitochondrial electron transport system may also create an optimal environment for the enzyme's function, leading to an indirect enhancement of its activity.

Moreover, L2HGDH can be affected by alterations in its methylation status, with certain methyl donors potentially increasing its stability or catalytic efficiency. Introducing compounds that influence the redox state within the mitochondria may also have a stimulating effect on the enzyme. The synthesis of coenzymes necessary for the enzyme's reactions can be supported by the provision of specific vitamins, which in turn can enhance the enzyme's performance in its respective metabolic pathways.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Ademetionine

29908-03-0sc-278677
sc-278677A
100 mg
1 g
$184.00
$668.00
2
(1)

Acts as a methyl donor in various reactions, potentially increasing stability or activity of L2HGDH through methylation of specific residues.

NAD+, Free Acid

53-84-9sc-208084B
sc-208084
sc-208084A
sc-208084C
sc-208084D
sc-208084E
sc-208084F
1 g
5 g
10 g
25 g
100 g
1 kg
5 kg
$57.00
$191.00
$302.00
$450.00
$1800.00
$3570.00
$10710.00
4
(2)

As a coenzyme for dehydrogenases, NAD+ is essential for L2HGDH functionality, providing the necessary electron acceptor role for the oxidative dehydrogenation reaction catalyzed by L2HGDH.

Coenzyme Q10

303-98-0sc-205262
sc-205262A
1 g
5 g
$71.00
$184.00
1
(1)

Supports mitochondrial electron transport chain, which could enhance the redox state and indirectly augment L2HGDH activity by optimizing the mitochondrial environment.

α-Ketoglutaric Acid

328-50-7sc-208504
sc-208504A
sc-208504B
sc-208504C
sc-208504D
sc-208504E
sc-208504F
25 g
100 g
250 g
500 g
1 kg
5 kg
16 kg
$33.00
$43.00
$63.00
$110.00
$188.00
$738.00
$2091.00
2
(1)

As part of the Krebs cycle, it may increase substrate availability for L2HGDH, facilitating its catalytic activity in the conversion of L-2-hydroxyglutarate to alpha-ketoglutarate.

Succinic acid

110-15-6sc-212961B
sc-212961
sc-212961A
25 g
500 g
1 kg
$45.00
$75.00
$133.00
(0)

As a Krebs cycle intermediate, it could enhance L2HGDH activity by influencing the cellular metabolic status and indirectly increasing the turnover of related metabolites.

Methylene blue

61-73-4sc-215381B
sc-215381
sc-215381A
25 g
100 g
500 g
$43.00
$104.00
$328.00
3
(1)

Acts as an artificial electron acceptor which could indirectly stimulate L2HGDH activity by influencing the redox balance within the mitochondria.

Pyruvic acid

127-17-3sc-208191
sc-208191A
25 g
100 g
$41.00
$96.00
(0)

As it enters the Krebs cycle, could enhance the flux of intermediates, potentially increasing the substrate availability for L2HGDH.

Fumaric acid

110-17-8sc-250031
sc-250031A
sc-250031B
sc-250031C
25 g
100 g
500 g
2.5 kg
$43.00
$57.00
$114.00
$228.00
(0)

As a Krebs cycle intermediate, might indirectly enhance L2HGDH activity through metabolic flux adjustments.

Malic acid

6915-15-7sc-257687
100 g
$130.00
2
(0)

Enhances the malate-aspartate shuttle, which could indirectly increase L2HGDH activity by improving NADH recycling in the mitochondria and thus the availability of NAD+.

Riboflavin

83-88-5sc-205906
sc-205906A
sc-205906B
25 g
100 g
1 kg
$41.00
$112.00
$525.00
3
(1)

As a precursor of FAD, riboflavin supplementation might indirectly enhance L2HGDH activity as FAD-dependent enzymes play a role in the Krebs cycle and related metabolic pathways.