L2HGDH Inhibitors
L2HGDH inhibitors operate by interfering with the metabolic pathways and enzyme cofactors that are critical for the proper function of L2HGDH. Some inhibitors work by disrupting the tricarboxylic acid (TCA) cycle, which is integral to cellular respiration and metabolism. For example, compounds that inhibit enzymes like isocitrate dehydrogenase, succinate dehydrogenase, and aconitase lead to a cascade of effects that ultimately reduce the functional activity of L2HGDH. This is due to the interconnected nature of metabolic pathways where altering the flux or concentrations of metabolic intermediates in the TCA cycle can indirectly inhibit the activity of L2HGDH. Additionally, inhibitors that affect the redox state within the cell, such as those that interfere with the mitochondrial electron transport chain, can change the NAD+/NADH ratio. This alteration is crucial since NAD+ is a cofactor necessary for L2HGDH activity, and any imbalance can lead to its functional inhibition.
Furthermore, some L2HGDH inhibitors target the enzymatic function by altering the availability or oxidation state of metal ion cofactors. Inhibitors that act on divalent cation-dependent enzymes can impede the metal ion cofactors that are essential for the catalytic activity of L2HGDH. Other inhibitors induce the production of reactive oxygen species (ROS), which can oxidize these cofactors, thereby inhibiting L2HGDH indirectly. Additionally, some compounds inhibit enzymes involved in sulfur transfer reactions, which are important for maintaining the function of L2HGDH cofactors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oxalomalic acid sodium salt | 89304-26-7 | sc-295985 sc-295985A | 1 mg 5 mg | $51.00 $153.00 | ||
This compound is an isocitrate dehydrogenase inhibitor that interrupts the TCA cycle. By doing so, it indirectly affects the availability of cofactors necessary for L2HGDH activity, therefore leading to its functional inhibition. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $36.00 | 1 | |
This tricarboxylic acid cycle inhibitor acts on enzymes requiring divalent cations, which may interfere with metal ion cofactors critical for L2HGDH function, resulting in decreased activity. | ||||||
Dimethyl malonate | 108-59-8 | sc-239778 sc-239778A | 250 ml 1 L | $49.00 $102.00 | 1 | |
As a competitive inhibitor of succinate dehydrogenase, this compound alters the TCA cycle flux. Since L2HGDH is involved in the metabolism of alpha-ketoglutarate derivatives, perturbation of the TCA cycle indirectly inhibits L2HGDH function. | ||||||
Itaconic acid | 97-65-4 | sc-250207 sc-250207A | 100 g 1 kg | $28.00 $51.00 | ||
This compound is an inhibitor of aconitase, which plays a role in the TCA cycle. Its action can lead to a buildup of citrate and isocitrate, potentially affecting L2HGDH's activity indirectly. | ||||||
Vitamin K3 | 58-27-5 | sc-205990B sc-205990 sc-205990A sc-205990C sc-205990D | 5 g 10 g 25 g 100 g 500 g | $25.00 $35.00 $46.00 $133.00 $446.00 | 3 | |
As a redox cycling compound, it generates reactive oxygen species (ROS) that can alter the oxidation state of cofactors necessary for the proper function of L2HGDH. | ||||||
Dichloroacetic acid | 79-43-6 | sc-214877 sc-214877A | 25 g 100 g | $60.00 $125.00 | 5 | |
This pyruvate dehydrogenase kinase inhibitor shifts metabolism from glycolysis to oxidative phosphorylation, which affects the metabolic state of the cell and indirectly inhibits L2HGDH by altering the balance of TCA cycle intermediates. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is another complex I inhibitor that disrupts NAD+/NADH homeostasis, thereby potentially inhibiting L2HGDH by impacting the cellular redox state. | ||||||
3-Nitropropionic acid | 504-88-1 | sc-214148 sc-214148A | 1 g 10 g | $80.00 $450.00 | ||
This compound is an irreversible inhibitor of succinate dehydrogenase, which can lead to alterations in the TCA cycle that indirectly inhibit L2HGDH by modifying the metabolic environment. | ||||||