Molecular structure of 3-Nitropropionic acid, CAS Number: 504-88-1
3-Nitropropionic acid (CAS 504-88-1)
Alternate Names:
beta-nitropropionic acid; Bovinocidin
Application:
3-Nitropropionic acid is an inhibitor used for research purposes
CAS Number:
504-88-1
Purity:
≥97%
Molecular Weight:
119.08
Molecular Formula:
C3H5NO4
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
3-Nitropropionic acid is a potent irreversible inhibitor of mitochondrial complex II enzyme, which causes dysfunction and oxidative stress in mitochondria. 3-Nitropropionic acid is an important research compound because it can simulate the effects on cells that result in the formation of Huntington′s disease. The oxidative stress observed in cells is believed to be a result of electron leakage from the mitochondria, which results in cell death. Studies indicate that Galantamine (sc-218556), a reversible acetylcholinesterase inhibitor can attenuate the effects of 3-Nitropropionic acid in rats.
3-Nitropropionic acid (CAS 504-88-1) References
- Metabolic profiling of 3-nitropropionic acid early-stage Huntington's disease rat model using gas chromatography time-of-flight mass spectrometry. | Chang, KL., et al. 2011. J Proteome Res. 10: 2079-87. PMID: 21355552
- Protective effects of chlorogenic acid in 3-nitropropionic acid induced toxicity and genotoxicity. | Alarcón-Herrera, N., et al. 2017. Food Chem Toxicol. 109: 1018-1025. PMID: 28478101
- Influence of 3-nitropropionic acid on physiological and behavioral responses in zebrafish larvae and adults. | Wiprich, MT., et al. 2020. Comp Biochem Physiol C Toxicol Pharmacol. 234: 108772. PMID: 32353558
- Fatal 3-Nitropropionic Acid Poisoning after Consuming Coconut Water. | Birkelund, T., et al. 2021. Emerg Infect Dis. 27: 278-280. PMID: 33350928
- Ellagic acid prevents 3-nitropropionic acid induced symptoms of Huntington's disease. | Sharma, P., et al. 2021. Naunyn Schmiedebergs Arch Pharmacol. 394: 1917-1928. PMID: 34061228
- Identification of cyclin D1 as a major modulator of 3-nitropropionic acid-induced striatal neurodegeneration. | Dietrich, P., et al. 2022. Neurobiol Dis. 162: 105581. PMID: 34871739
- Telmisartan neuroprotective effects in 3-nitropropionic acid Huntington's disease model in rats: Cross talk between PPAR-γ and PI3K/Akt/GSK-3β pathway. | Abdel Rasheed, NO. and Ibrahim, WW. 2022. Life Sci. 297: 120480. PMID: 35278421
- Inosine attenuates 3-nitropropionic acid-induced Huntington's disease-like symptoms in rats via the activation of the A2AR/BDNF/TrKB/ERK/CREB signaling pathway. | El-Shamarka, ME., et al. 2022. Life Sci. 300: 120569. PMID: 35472453
- Addressing Peroxisome Proliferator-Activated Receptor-gamma in 3-Nitropropionic Acid-Induced Striatal Neurotoxicity in Rats. | Mansour, RM., et al. 2022. Mol Neurobiol. 59: 4368-4383. PMID: 35553009
- Harmine prevents 3-nitropropionic acid-induced neurotoxicity in rats via enhancing NRF2-mediated signaling: Involvement of p21 and AMPK. | Habib, MZ., et al. 2022. Eur J Pharmacol. 927: 175046. PMID: 35623405
- Diapocynin neuroprotective effects in 3-nitropropionic acid Huntington's disease model in rats: emphasis on Sirt1/Nrf2 signaling pathway. | Ibrahim, WW. and Abdel Rasheed, NO. 2022. Inflammopharmacology. 30: 1745-1758. PMID: 35639233
- Modulation of adenosine signaling reverses 3-nitropropionic acid-induced bradykinesia and memory impairment in adult zebrafish. | Wiprich, MT., et al. 2022. Prog Neuropsychopharmacol Biol Psychiatry. 119: 110602. PMID: 35843370
- Berberine Ameliorate Haloperidol and 3-Nitropropionic Acid-Induced Neurotoxicity in Rats. | Kadir, A., et al. 2022. Neurochem Res. 47: 3285-3297. PMID: 35876936
- Analysis of 3-nitropropionic acid in Fabaceae plants by HPLC-MS/MS. | Takács, O., et al. 2022. Phytochem Anal. 33: 1205-1213. PMID: 36111358
- Neuroprotective effect of silymarin against 3-Nitropropionic acid-induced neurotoxicity in rats. | Chandolia, P., et al. 2022. Curr Res Pharmacol Drug Discov. 3: 100130. PMID: 36568269
Inhibitor of:
α-KGD, apoOL, CDNF, Citrate Lyase, D10Jhu81e, D2HGDH, DHRS12, EG240549, EG623286, FAHD2A, FDX1L, Fumarylacetoacetase, GCDH, HDMCP, HIBADH, IDH3G, L2HGDH, LHFPL5, LOC283398, MCCA, MCEE, MDH2, Misato, NUBPL, OSAP, PDDC1, PINK1, Ros, SDHA, SDHAF2, SDHB, SDHC, SDHD, SDR-O, SOD-3, SQRDL, Tim13A/B, and TMEM126A.Activator of:
GPR91, and sMtCK.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-Nitropropionic acid, 1 g | sc-214148 | 1 g | $82.00 | |||
3-Nitropropionic acid, 10 g | sc-214148A | 10 g | $459.00 |