Dichloroacetic acid CAS: 79-43-6
MF: C2H2Cl2O2
MW: 128.94
A mitochondrial PDK (pyruvate dehydrogenase kinase) inhibitor.

Dichloroacetic acid (CAS 79-43-6)

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Synonym: Acetic acid; Urner's liquid
Application: A mitochondrial PDK (pyruvate dehydrogenase kinase) inhibitor
CAS Number: 79-43-6
Purity: ≥98%
Molecular Weight: 128.94
Molecular Formula: C2H2Cl2O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Dichloroacetic acid is a simple halogenated acetic acid compound with two chlorides at the α-position. Dichloroacetic acid has been demonstrated to inhibit mitochondrial PDK (pyruvate dehydrogenase kinase) and to shift cellular metabolism from glycolysis to glucose oxidation, and these activities have been correlated to interruption of apoptosis resistance in certain cancer cell lines.


References

1. Bonnet, S., et al. 2007. Cancer Cell. 11: 37-51. PMID: 17222789

Physical State :
Liquid
Storage :
Store at room temperature
Melting Point :
9-11° C (lit.)
Boiling Point :
194° C (lit.)
Density :
1.56 g/mL at 25° C
Refractive Index :
n20/D 1.4663
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
AG6125000
PubChem CID :
6597
Merck Index :
14: 3050
MDL Number :
MFCD00004223
EC Number :
201-207-0
Beilstein Registry :
1098596
SMILES :
OC(=O)C(Cl)Cl

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Certificate of Analysis

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is there a difference between the powder and the liquid and if you can mail it to colombia thanks

Asked by: marine 1979
Thank you for your question. This product is a liquid, but we have no information in comparison to this chemical as a powder. For accurate availability, shipping and pricing information regarding our chemical products, please contact Customer Service or reach out directly to your local distributor
Answered by: Tech Service
Date published: 2020-02-24

I'm assuming your 25g bottle would have approximately 15ml. Correct?

Asked by: RPCMD
Thank you for your inquiry.The density of sc-214877 is 1.56 g/mL at 25 °C.so 25g should be about 15-16ml. For more detailed information about this question, please call us toll-free at (800) 457-3801 option 2, e-mail <[email protected]>, or use the live chat on our website.
Answered by: Technical Service 11
Date published: 2017-12-15

What assay can I used to check if Dchloroacetic acid inhibits PDK activity?

Asked by: Thandeka
Thank you for your question. We are unable to offer any specific recommendation on how to use Dichloroacetic acid (CAS 79-43-6) to study inhibition of PDK activity. We would recommend you search in the primary literature to see how other investigators are using the chemical for this purpose. There is one reference listed on our website that may be a useful place to start your research. 1. Bonnet, S., et al. 2007. Cancer Cell. 11: 37-51. PMID: 17222789
Answered by: Technical Support
Date published: 2020-01-15
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