KV4.2 Activators
KV4.2 activators are a class of compounds that enhance the function of the KV4.2 potassium channel, a protein that plays a critical role in shaping the electrical signals in cardiac and neuronal tissues. These activators can operate through a variety of mechanisms, including direct interaction with the channel or indirect modulation of cellular pathways that affect the channel's activity. Some activators work by binding to specific sites on the KV4.2 channel, stabilizing it in the open state and thereby increasing potassium conductance. Others may increase the channel's sensitivity to voltage changes across the cell membrane, thus promoting a higher open probability at given membrane potentials. Direct activators often have a molecular structure that allows them to interact specifically with the channel's gating machinery, providing targeted modulation of its electrical signaling properties.
Indirect activators, on the other hand, affect the KV4.2 channel's activity through alterations in cellular signaling cascades. These compounds may elevate levels of intracellular messengers like cAMP, which in turn activates protein kinases that phosphorylate the KV4.2 channel, leading to increased channel activity. Alternatively, indirect activators may inhibit phosphatases responsible for the dephosphorylation of the channel, thereby maintaining it in a phosphorylated, and more active, state.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylyl cyclase, increasing cAMP and activating PKA, which can phosphorylate KV4.2 channels enhancing their activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
A beta-adrenergic receptor agonist that increases cAMP levels, potentially leading to the activation of KV4.2 via PKA phosphorylation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
A nonspecific inhibitor of phosphodiesterases, increases cAMP by preventing its breakdown, which may enhance KV4.2 channel activity via PKA. | ||||||
Sp-cAMPS | 93602-66-5 | sc-201571 | 1 mg | $97.00 | 3 | |
A cAMP analog that activates PKA; PKA can then phosphorylate and increase the activity of KV4.2 channels. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Inhibits protein synthesis and can activate stress-activated protein kinases, which may indirectly enhance KV4.2 function. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
A cell-permeable cAMP analog that can activate PKA and thereby may increase KV4.2 activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
By stimulating adrenergic receptors, it increases cAMP and activates PKA, which may enhance KV4.2 channel activity. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
A PKA inhibitor that in some contexts can lead to feedback mechanisms that upregulate cAMP levels, potentially increasing KV4.2 activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
A phosphodiesterase-4 inhibitor that raises cAMP levels, potentially enhancing KV4.2 channel phosphorylation and activity. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
A PDE1 inhibitor that can elevate cAMP levels, potentially leading to the activation of KV4.2 channels. | ||||||