KRTAP19-5 Inhibitors
KRTAP19-5 inhibitors are a specific class of chemical compounds that interact with keratin-associated protein 19-5 (KRTAP19-5), a protein involved in the regulation of hair fiber formation. KRTAP proteins belong to a family of structural proteins that play a critical role in forming the matrix of hair and other keratinized tissues by interacting with keratin intermediate filaments. These inhibitors function by selectively targeting the molecular pathways associated with KRTAP19-5, impacting the protein's conformation or its ability to participate in the assembly of the hair matrix. Structurally, KRTAP19-5 inhibitors often share key molecular features that allow them to bind specifically to the protein or its associated complexes, preventing its normal function in hair fiber assembly. Their specificity makes them valuable in studying the biochemical processes underlying keratinization and the structural properties of hair.
On the molecular level, KRTAP19-5 inhibitors may exert their effects by blocking key binding sites, interfering with protein-protein interactions, or altering the stability of the protein. These compounds can vary widely in chemical structure, from small molecules to larger peptides or synthetic analogs designed to mimic the protein's natural interaction partners. By disrupting KRTAP19-5, these inhibitors offer insights into the mechanisms of keratin-associated protein activity, particularly within hair follicle biology. They are also useful as molecular tools to investigate the regulation of keratin network assembly and the mechanical properties of keratinized tissues. Research into these inhibitors allows for a deeper understanding of the complex processes that govern protein function and the structural integrity of hair.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may lead to the hyperacetylation of histones associated with the KRTAP19-5 gene, resulting in a tightly packed chromatin state that is less accessible to transcription machinery, thereby decreasing its expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This agent could induce hypomethylation at the promoter region of the KRTAP19-5 gene, which may lead to the recruitment of repressive transcription factors, resulting in decreased expression levels of KRTAP19-5. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
By binding to GC-rich regions within the DNA, Mithramycin A might directly block the transcriptional start site of the KRTAP19-5 gene, leading to a reduction in its mRNA transcript synthesis. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin might downregulate the translation of KRTAP19-5 by inhibiting the mTOR pathway, which plays a pivotal role in protein synthesis, thus reducing the overall expression level of KRTAP19-5. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
By targeting RNA polymerase II and halting its transcriptional elongation capabilities, DRB could specifically result in premature termination of KRTAP19-5 mRNA synthesis, effectively reducing its expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin could downregulate the expression of KRTAP19-5 by hindering the phosphorylation of transcription factors that are essential for the initiation of its transcription. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid might repress the expression of KRTAP19-5 by binding to retinoic acid receptors that interact with the KRTAP19-5 gene promoter, thus inhibiting its transcriptional activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
(-)-Epigallocatechin Gallate could inhibit the expression of KRTAP19-5 by obstructing the activation of NF-κB, a transcription factor that may be necessary for the gene's expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
This compound could reduce KRTAP19-5 expression by activating the expression of histone deacetylases, leading to chromatin condensation and subsequent transcriptional repression of the gene. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone might decrease KRTAP19-5 expression by activating glucocorticoid receptors that bind to glucocorticoid response elements in the KRTAP19-5 gene promoter, leading to transcriptional repression. | ||||||