KRTAP10-6 Inhibitors
KRTAP10-6 inhibitors are chemical compounds that specifically target and inhibit the activity of keratin-associated protein 10-6 (KRTAP10-6). KRTAPs, in general, are small, cysteine-rich proteins that are associated with keratin in hair and wool fibers. KRTAP10-6 belongs to the family of high sulfur proteins, which are important for the structural integrity and mechanical properties of keratin fibers. Inhibitors of KRTAP10-6 interfere with its binding and interaction with keratin filaments, potentially altering the assembly or stabilization of keratin structures. The inhibition of this particular protein can result in changes to the disulfide bond network that is crucial for the strength and elasticity of keratin, affecting how keratin fibers organize and respond to mechanical stress.
Chemically, KRTAP10-6 inhibitors can vary in structure, but many are designed to disrupt specific protein-protein interactions or the formation of covalent bonds within the keratin matrix. These inhibitors may function through direct binding to the protein's active or binding sites, preventing KRTAP10-6 from associating with keratin filaments. Alternatively, they may act by modulating the protein's conformational state, which influences how it interacts with keratin. The structural properties of KRTAP10-6, including its rich cysteine content, make it a target for inhibitors that can interfere with cysteine-mediated bonding. The exact molecular mechanisms of inhibition can vary depending on the chemical nature of the inhibitor, which can include small molecules, peptides, or larger biomolecules designed to specifically disrupt KRTAP10-6 functions in keratin assembly.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This cytidine analog could cause DNA demethylation of promoter regions specific to KRTAP10-6, leading to a downregulation of its transcription. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
By inhibiting histone deacetylases, Trichostatin A might promote a more closed chromatin conformation around the KRTAP10-6 gene, thereby decreasing its transcriptional activity. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid can extend the acetylation of histones associated with the KRTAP10-6 gene, potentially leading to its transcriptional repression through chromatin remodeling. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate may attenuate the transcription of KRTAP10-6 by inhibiting histone deacetylase, which can result in a condensed chromatin state less conducive to gene expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
By binding to GC-rich DNA sequences proximal to the KRTAP10-6 locus, Mithramycin A could obstruct the binding of specific transcription factors necessary for KRTAP10-6 gene expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D intercalates between DNA bases, which could specifically hinder the progression of RNA polymerase at the KRTAP10-6 gene, thereby inhibiting its mRNA synthesis. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Through binding to its receptors, Retinoic Acid might repress KRTAP10-6 gene transcription by altering the recruitment of transcription factors and co-repressors to its promoter region. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which could lead to a reduced translational capacity for KRTAP10-6 mRNA, thereby decreasing the protein levels produced from this gene. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
As a specific inhibitor of PI3K, LY 294002 has the potential to downregulate KRTAP10-6 expression by hindering AKT phosphorylation and subsequent transcriptional activation of growth-related genes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, by blocking the PI3K pathway, might indirectly lead to a decrease in KRTAP10-6 expression due to reduced transcriptional activity linked to cell survival and growth signals. | ||||||