KRTAP1-1 Inhibitors
KRTAP1-1 inhibitors for instance, retinoids like retinoic acid and its derivatives, alitretinoin and tretinoin, are known to affect gene expression of various proteins, including those in the keratin family. They can lead to changes in the synthesis of keratin-associated proteins within the hair follicle. Cyclosporine A, while primarily an immunosuppressant, has been observed to have an effect on hair growth, which implies it may indirectly influence the expression or function of proteins like KRTAP1-1 by altering cytokine profiles. Minoxidil and bimatoprost are compounds that stimulate hair growth and may thus alter the balance of keratin-associated proteins within the hair matrix.
Hormonal pathways are essential in hair follicle biology, and modulators like finasteride and spironolactone can lead to changes in hair growth patterns, which could in turn affect keratin protein expression. Vitamin D3 and EGCG have been suggested to have roles in hair cycle regulation and hormonal balance, respectively, which can affect the structural components of hair. Antifungal agents like ketoconazole and anti-inflammatory compounds such as hydrocortisone can also impact skin and hair health, thereby potentially influencing keratin expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A metabolite of Vitamin A, retinoic acid can regulate gene expression, potentially affecting keratin protein synthesis. | ||||||
9-cis-Retinoic acid | 5300-03-8 | sc-205589 sc-205589B sc-205589C sc-205589D sc-205589A | 1 mg 25 mg 250 mg 500 mg 5 mg | $71.00 $424.00 $3121.00 $5722.00 $148.00 | 10 | |
A derivative of retinoic acid which can modulate keratin gene expression through retinoid receptors. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
An immunosuppressant that can alter hair growth by affecting cytokine profiles, potentially influencing KRTAP1-1. | ||||||
Minoxidil (U-10858) | 38304-91-5 | sc-200984 sc-200984A | 100 mg 1 g | $69.00 $351.00 | ||
A vasodilator that can stimulate hair growth and may affect the expression of keratin-associated proteins. | ||||||
Bimatoprost | 155206-00-1 | sc-205224 sc-205224A | 1 mg 5 mg | $120.00 $464.00 | 1 | |
A prostaglandin analog used to enhance eyelash growth, could alter keratin expression in hair follicles. | ||||||
Finasteride | 98319-26-7 | sc-203954 | 50 mg | $105.00 | 3 | |
An inhibitor of 5-alpha-reductase which can affect hair loss and growth, possibly influencing keratin protein expression. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $109.00 | 3 | |
An aldosterone antagonist with potential anti-androgenic effects that may impact hair growth and keratin protein levels. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Can regulate the hair cycle and potentially influence the expression of keratin-associated proteins. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
May have an effect on hair growth by modulating hormonal activity. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
An antifungal agent that can affect hair growth, potentially altering the expression of keratin proteins. | ||||||