Krox-26 Activators
The class of chemicals identified as activators for Krox-26 share a common feature in that they all influence transcriptional regulation through various biochemical and cellular pathways. These pathways include cyclic nucleotide signaling, hormone receptor-mediated transcription, kinase signaling cascades, epigenetic modifications, and metabolic stress responses. These chemicals achieve their effects through the activation of protein kinases such as PKA and PKC, inhibition of DNA and histone modifying enzymes, or through the modulation of specific transcription factors. Their activities lead to a range of cellular responses that involve changes in gene expression patterns, which could feasibly encompass the upregulation of Krox-26.
The activation mechanisms of these chemicals are linked to their ability to either alter the phosphorylation state of proteins, change the acetylation or methylation status of histones and DNA, or modulate the cellular concentration of second messengers such as cAMP. Such changes at the cellular level can lead to a cascade of regulatory events, culminating in the activation of transcription factors, among which Krox-26 could be included. Through the manipulation of intracellular signaling and epigenetic landscape, the activity of Krox-26 could be indirectly modulated, leading to its increased activity within the cell. These activators are integral in cellular processes that range from gene expression regulation to response to metabolic conditions, reflecting the interconnectivity of cellular signaling and the complex regulation of transcription factor activities.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl cAMP, a cAMP analog, activates PKA. PKA then can phosphorylate transcription factors, enhancing their activity. If Krox-26 activity is modulated by PKA-mediated phosphorylation, its activity would be enhanced in response to increased cellular cAMP. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid modulates gene expression by activating retinoic acid receptors which can then bind to retinoic acid response elements in gene promoters. If Krox-26 is a downstream target, its expression would be upregulated by retinoic acid-mediated transcription. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
β-estradiol binds estrogen receptors that may regulate gene transcription through the estrogen response elements. If Krox-26 gene expression is estrogen-responsive, β-estradiol can enhance its expression by promoting transcriptional activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can modulate transcription factors. If Krox-26 activity is regulated via PKC signaling, PMA can upregulate its activity by promoting the phosphorylation of proteins in the PKC pathway. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor. It leads to chromatin remodeling and can increase the transcription of certain genes. If the Krox-26 gene promoter is responsive, its expression could be enhanced by the action of sodium butyrate. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
BIX 01294 is a histone methyltransferase G9a inhibitor, which causes epigenetic modifications leading to transcriptional activation of certain genes. If the Krox-26 gene is epigenetically regulated by G9a, inhibition could result in its increased expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A DNA methyltransferase inhibitor, which leads to demethylation and often activation of gene expression. If the Krox-26 gene is silenced by DNA methylation, this compound would induce its expression by demethylation. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A-769662 activates AMP-activated protein kinase (AMPK). If Krox-26 is part of the energy balance and metabolic stress response pathway, activation of AMPK could enhance its activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, a member of the sirtuin family of protein deacetylases. If Krox-26 is regulated by acetylation status, activation of SIRT1 can lead to its deacetylation and activation. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc Pyrithione can activate metal response element-binding transcription factor-1 (MTF-1), influencing gene expression in response to metal ions. If Krox-26 is regulated by MTF-1, its activity could be modulated by this compound. | ||||||