KLRI1 inhibitors constitute a class of chemical compounds designed to selectively target and interfere with the activity of KLRI1, a protein or molecule with functions associated with immune cell recognition. KLRI1, also known as Klrb1c or Nkrp1c, is a member of the natural killer cell receptor gene family, predominantly expressed on the surface of natural killer (NK) cells and some T cells. These receptors play a crucial role in immune surveillance, enabling immune cells to recognize specific molecules on target cells, such as viruses, tumor cells, or stressed cells.
The primary mechanism of action for KLRI1 inhibitors typically involves their interaction with the KLRI1 protein or its associated molecules, leading to the modulation of receptor function. By inhibiting KLRI1, these compounds have the ability to influence immune cell interactions with target cells and modulate immune responses. However, the specific ligands and signaling pathways associated with KLRI1 are still areas of active investigation. Scientists studying KLRI1 inhibitors aim to unravel the precise roles and functions of KLRI1 in immune cell biology, contributing to our understanding of its significance within the context of immune recognition and immune regulation. These inhibitors serve as valuable tools for advancing our knowledge of KLRI1 and its roles in immune surveillance. In this context, they contribute to expanding our understanding of the intricate world of immune receptors and their impact on immune cell function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide has been shown to inhibit the transcription of a broad range of genes by affecting RNA polymerase II activity. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
This compound inhibits eukaryotic protein synthesis by interfering with the translocation step in the elongation phase on ribosomes. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds DNA and prevents RNA synthesis by inhibiting the movement of RNA polymerase along the DNA. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 inhibits the proteasome, which could lead to increased levels of regulatory proteins involved in gene expression. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
A cyclin-dependent kinase inhibitor that can lead to cell cycle arrest and can modulate transcriptional activity. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A DNA methyltransferase inhibitor that can reactivate genes silenced by methylation, affecting gene expression profiles. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
An inhibitor of histone deacetylases which can alter chromatin structure and gene expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound is incorporated into RNA and DNA and can inhibit DNA methyltransferase, affecting gene expression. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Primarily known for proteasome inhibition, it can also influence various signaling pathways, potentially affecting gene expression. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
A selective inhibitor of class I histone deacetylases, leading to alterations in chromatin structure and gene expression. | ||||||