KLHL7 Activators
KLHL7 Activators are a class of chemical compounds that directly or indirectly enhance the functional activity of the KLHL7 protein. These compounds can influence specific signaling pathways or cellular processes that are directly involved in modulating the activity of KLHL7. For instance, forskolin and isoproterenol both act by increasing intracellular cAMP levels, which subsequently activates PKA. This kinase has a broad range of targets and can phosphorylate proteins that may interact with or regulate KLHL7, thus enhancing its functional activity. Similarly, PMA activates PKC, which is involved in phosphorylating target proteins that might have a regulatory relationship with KLHL7, either enhancing its function or stability within the cellular context.
Other activators like EGF and insulin operate through receptor tyrosine kinase pathways, such as the MAPK/ERK and PI3K/Akt pathways, respectively. These pathways can activate downstream transcription factors or kinases that ultimately increase the expression or activity of proteins that interact with KLHL7.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, which increases cAMP levels in the cell. Elevated cAMP activates PKA (protein kinase A), which can phosphorylate and enhance the activity of a wide range of proteins, including potentially KLHL7, if KLHL7 is a substrate of PKA or is regulated by PKA-phosphorylated proteins. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which is involved in various signaling pathways. PKC can phosphorylate specific target proteins that may interact with KLHL7, leading to its functional activation or stabilization within the cell. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calmodulin-dependent kinase (CaMK). CaMK can phosphorylate proteins that modulate the function of KLHL7 or its associated complexes. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin triggers the PI3K/Akt signaling pathway, which is involved in cell survival and metabolism. Akt can phosphorylate a multitude of substrates that might have a regulatory relationship with KLHL7, influencing its activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK-3β, a kinase that phosphorylates and regulates various proteins. Inhibition of GSK-3β can prevent the degradation of proteins that may stabilize or enhance the activity of KLHL7. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels, similar to forskolin, thereby activating PKA. PKA subsequently could phosphorylate proteins that either directly interact with KLHL7 or modulate its stability and activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase 4 (PDE4), leading to an increase in cAMP levels in the cell. The resultant activation of PKA can enhance the phosphorylation state of proteins that regulate KLHL7 activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP, leading to their accumulation. This can activate PKA and PKG, which may affect proteins that modulate KLHL7 activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
Calyculin A is an inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A), which prevents dephosphorylation of proteins. Persistent phosphorylation can enhance the activity of proteins that regulate or interact with KLHL7. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A-23187 is a calcium ionophore like ionomycin, and it similarly increases intracellular calcium levels, potentially activating calcium-dependent signaling pathways or proteins that interact with or regulate KLHL7. | ||||||