KLF17 Activators
KLF17 Activators, also known as Krüppel-like factor 17 activators, belong to a class of chemical compounds that have garnered significant attention in the field of molecular biology and genetics. KLF17, short for Krüppel-like factor 17, is a transcription factor, a protein that plays a crucial role in regulating gene expression. Specifically, KLF17 is a member of the Krüppel-like factor (KLF) family of transcription factors, which are involved in the intricate control of gene transcription, cell proliferation, and differentiation.
KLF17 Activators are compounds designed to enhance the activity of KLF17. KLF17 itself has been identified as a key player in various biological processes, including embryonic development, cell cycle regulation, and immune system modulation. It exerts its effects by binding to specific DNA sequences and influencing the expression of downstream target genes. Activating KLF17 can lead to the upregulation of genes associated with these processes, thereby influencing various cellular functions. Research into KLF17 activators aims to better understand the intricate regulatory networks that govern these biological processes. By manipulating KLF17 activity, scientists hope to gain insights into the underlying mechanisms of gene regulation and discover new ways to modulate cellular behavior for various scientific and biomedical purposes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase (HDAC) inhibitor. It activates KLF17 by inhibiting HDAC enzymes, leading to increased histone acetylation in the promoter region of the KLF17 gene. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is another HDAC inhibitor. It activates KLF17 by promoting histone acetylation, thereby increasing the expression of KLF17. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates KLF17 through the activation of SIRT1 (sirtuin 1), a NAD+-dependent deacetylase. SIRT1 deacetylates histones and transcription factors, including KLF17, leading to increased KLF17 expression. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates KLF17 indirectly by stimulating AMP-activated protein kinase (AMPK). Activated AMPK can modulate various signaling pathways that promote KLF17 expression. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone is a thiazolidinedione compound that activates KLF17 through peroxisome proliferator-activated receptor gamma (PPARγ) activation. PPARγ is a transcription factor that regulates KLF17 gene expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin activates KLF17 through multiple mechanisms, including inhibition of NF-κB, a transcription factor that can suppress KLF17 expression. Curcumin's anti-inflammatory properties contribute to KLF17 activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid activates KLF17 through retinoic acid receptors (RARs). When retinoic acid binds to RARs, it promotes the transcription of genes, including KLF17, that are involved in cell differentiation and development. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates KLF17 by increasing intracellular levels of cyclic AMP (cAMP). Elevated cAMP activates the cAMP response element binding protein (CREB), which binds to the KLF17 promoter and enhances its transcription. | ||||||
3,3′-Diindolylmethane | 1968-05-4 | sc-204624 sc-204624A sc-204624B sc-204624C sc-204624D sc-204624E | 100 mg 500 mg 5 g 10 g 50 g 1 g | $36.00 $64.00 $87.00 $413.00 $668.00 $65.00 | 8 | |
DIM activates KLF17 by promoting its expression. The exact mechanism of action may involve interactions with intracellular signaling pathways and transcription factors. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $325.00 $632.00 $1428.00 $2450.00 $400.00 | 32 | |
Calcitriol activates KLF17 through vitamin D receptor (VDR) activation. The VDR binds to the KLF17 promoter region, leading to increased KLF17 gene transcription. | ||||||