KLF12 Activators
KLF12's role as a transcription factor in various cellular contexts makes it a target of interest for modulation by diverse biochemical pathways. Indirect activators of KLF12 might include compounds that alter cellular signaling or epigenetic status, thereby affecting KLF12 expression or its activity at target genes. Agents such as Retinoic Acid, all trans and 5-Aza-2′-Deoxycytidine might influence KLF12 by altering the differentiation status of cells or the epigenetic landscape, respectively. Retinoic Acid, all trans, through its role in cell differentiation, might change the transcriptional demands on KLF12, leading to alterations in its activity. Similarly, 5-Aza-2′-Deoxycytidine could reactivate genes that are epigenetically silenced, including possibly KLF12 itself or its target genes, thereby affecting its functional role in the cell.
Additional compounds such as Trichostatin A, Forskolin, and PMA work through histone modification, cAMP signaling, and PKC activation, respectively, each potentially altering the cellular environment in which KLF12 operates. Trichostatin A's effect on chromatin can make certain genes more accessible to transcription factors like KLF12, altering its ability to regulate gene expression. Forskolin and PMA, by modifying signaling pathways, might lead to changes in the phosphorylation status of KLF12 or its cofactors, altering its activity. On the other hand, compounds like Rapamycin and Lithium Chloride affect broader cell growth and signaling pathways, potentially altering the expression or demand for KLF12 in processes like cell growth, apoptosis, and the response to cellular stress. Each of these compounds represents a possible avenue through which the activity or expression of KLF12 might be modulated, reflecting the interconnected nature of signaling pathways, transcriptional regulation, and cellular context in determining the function of key transcription factors such as KLF12.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid, all trans is involved in cell differentiation and apoptosis and affects the expression of a wide range of genes. It may influence KLF12 activity indirectly by altering cellular differentiation pathways or gene expression profiles. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
As a DNA methyltransferase inhibitor, 5-Aza-2′-Deoxycytidine can lead to demethylation and reactivation of silenced genes. It might indirectly enhance KLF12 expression by changing the epigenetic state of its promoter or other regulatory regions. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can lead to a more relaxed chromatin structure and affect gene expression. It may increase KLF12 expression or alter its activity by changing the acetylation status of histones around its target genes. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin elevates intracellular cAMP levels and activates PKA, leading to diverse effects on cellular functions and gene expression. It might indirectly affect KLF12 activity through these broad cellular changes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates Protein Kinase C (PKC) and can influence many signaling pathways. Through its broad effects on cell signaling, PMA might indirectly affect KLF12 activity or expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
(-)-Epigallocatechin Gallate is a polyphenol found in green tea with antioxidant properties. It has been shown to affect several signaling pathways and might indirectly modulate KLF12 expression or activity through its broad cellular effects. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin affects various cellular processes, including inflammation and apoptosis, and might modulate KLF12 activity by influencing these pathways or affecting the expression of genes regulated by KLF12. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor affecting cell growth and metabolism. It could potentially influence the cell cycle and DNA damage response pathways, indirectly affecting the role of KLF12 in these processes. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium is known to inhibit GSK-3β, a kinase involved in numerous signaling pathways. By modulating pathways associated with GSK-3β, Lithium Chloride might indirectly affect the signaling context and activity of KLF12. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate is a histone deacetylase inhibitor and can affect gene expression. It might indirectly influence KLF12 activity by altering the expression of proteins involved in the signaling pathways where KLF12 functions. | ||||||