KLF12 Antibody (NQ-C45): sc-134373

KLF12 Antibody (NQ-C45) is a mouse monoclonal IgG2a kappa light chain antibody that detects KLF12 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-KLF12 antibody (NQ-C45) is available as a non-conjugated format. KLF12, also known as AP2REP or HSPC122, is a crucial member of the Krüppel-like factor family, which consists of zinc finger-containing transcription factors that play significant roles in regulating various cellular processes, including growth, differentiation, and embryogenesis. KLF12 is a 402 amino acid protein primarily localized in the nucleus, where KLF12 exerts function by binding to specific DNA sequences. Notably, KLF12 contains three C2H2-type zinc fingers, which are essential for DNA-binding capability. KLF12 acts as a strong repressor of AP-2α transcription by binding to a regulatory element in the AP-2α gene promoter, thereby influencing gene expression patterns critical for cellular development and function. Additionally, KLF12 exists in two isoforms due to alternative splicing, which may contribute to functional diversity and regulatory mechanisms within the cell.

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KLF12 Antibody (NQ-C45) References:

1. Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12).  |  Roth, C., et al. 2000. Genomics. 63: 384-90. PMID: 10704285
2. Expression of AP-2 alpha in SV40 immortalized human lung fibroblasts is associated with a distinct pattern of cytosine methylation in the AP-2 alpha promoter.  |  Zhu, CH., et al. 2001. Biochim Biophys Acta. 1519: 85-91. PMID: 11406275
3. A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes.  |  Rozenblum, E., et al. 2002. Hum Genet. 110: 111-21. PMID: 11935316
4. Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter.  |  Suda, S., et al. 2006. Biochem Biophys Res Commun. 344: 246-52. PMID: 16615998
5. Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility.  |  Julià, A., et al. 2008. Arthritis Rheum. 58: 2275-86. PMID: 18668548
6. Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor.  |  Imhof, A., et al. 1999. Mol Cell Biol. 19: 194-204. PMID: 9858544