KIF18B Activators
The KIF18B activators can be categorized based on their capacity to modulate the complex interplay of intracellular pathways directly or indirectly linked with KIF18B, particularly concerning microtubule dynamics. Given KIF18B's central role in such dynamics, alterations in associated pathways can spur a more pronounced KIF18B function.
A significant portion of these activators, such as Rapamycin and Lithium Chloride, exert their effects by targeting key cellular pathways that invariably interlink with the functions of microtubules. For instance, mTOR inhibition by Rapamycin can lead to shifts in cellular homeostasis, indirectly urging KIF18B to step up its activity in an attempt to restore balance. Similarly, agents that influence cAMP levels, including Forskolin, Rolipram, and various cAMP analogs, hold the potential to impact a wide range of cellular processes that are tied, directly or indirectly, to the functions of KIF18B. By perturbing these pathways, there's an inherent push towards the enhanced activity of KIF18B to regulate and maintain proper microtubule dynamics. Collectively, these activators underscore the intertwined nature of cellular processes and the adaptability mechanisms, of which KIF18B is a pivotal component, to ensure cellular integrity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
This mTOR inhibitor can influence microtubule dynamics. By inhibiting mTOR, cells might boost KIF18B activity to help maintain cellular homeostasis in terms of microtubule dynamics. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
A GSK3β inhibitor, Lithium chloride can impact various cellular processes including those involving microtubules. Modulation of this pathway may lead to elevated KIF18B activity to manage microtubule dynamics. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
By elevating cAMP levels and activating PKA, Forskolin can influence a variety of cellular pathways including those tied to microtubule dynamics, possibly driving enhanced KIF18B activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
This PDE4 inhibitor raises intracellular cAMP levels, which can indirectly modulate pathways wherein KIF18B plays a role, prompting increased activity of KIF18B. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
As a cAMP analog, it can influence pathways associated with microtubule dynamics, which might lead to increased KIF18B function. | ||||||
8-CPT-cAMP | 93882-12-3 | sc-201569 sc-201569A | 20 mg 100 mg | $87.00 $316.00 | 19 | |
Another cAMP analog, it potentially modulates microtubule-associated pathways, nudging KIF18B towards elevated activity. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $109.00 $322.00 | 3 | |
As a phosphodiesterase inhibitor, it can elevate cAMP levels, indirectly influencing KIF18B-related pathways, and thereby possibly activating KIF18B. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Influences SIRT1 pathway, which has interplays with microtubule dynamics. This can lead to a condition wherein KIF18B's role becomes more pronounced. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Being a non-specific PDE inhibitor, IBMX can increase cellular cAMP levels. This may have downstream effects that culminate in the enhanced activity of KIF18B. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Mimics cAMP's actions and can affect associated pathways, potentially leading to increased KIF18B activity. | ||||||