Date published: 2025-10-25

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KIF18B Inhibitors

KIF18B inhibitors represent a group of chemical compounds that are poised to modulate the activity or expression of the kinesin-like protein KIF18B, a member of the extensive kinesin superfamily of motor proteins. KIF18B plays a fundamental role in the modulation of microtubule dynamics, especially during mitosis. Given the importance of microtubules in cellular processes, accurate regulation is vital. The role of KIF18B, particularly in conjunction with other proteins like KIF2C, is pivotal in ensuring proper microtubule dynamics, as they together constitute the major microtubule plus-end depolymerizing activity in mitotic cells. This crucial interaction ensures accurate chromosome alignment and segregation, emphasizing the importance of finely-tuned microtubule dynamics in cell health and integrity. The compounds listed as KIF18B inhibitors, such as paclitaxel, vinblastine, and colchicine, to name a few, generally exert their effects by targeting microtubules or associated processes. For instance, paclitaxel stabilizes microtubules, preventing their depolymerization, while vinblastine and colchicine inhibit microtubule formation and polymerization, respectively. The hypothesis is that by modulating microtubule dynamics, these compounds could indirectly influence the function or expression of KIF18B. In essence, the landscape on which KIF18B acts, i.e., the microtubules, is altered, which can lead to changes in KIF18B's activity or expression.

Items 1 to 10 of 11 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Taxol

33069-62-4sc-201439D
sc-201439
sc-201439A
sc-201439E
sc-201439B
sc-201439C
1 mg
5 mg
25 mg
100 mg
250 mg
1 g
$40.00
$73.00
$217.00
$242.00
$724.00
$1196.00
39
(2)

Paclitaxel stabilizes microtubules and prevents their depolymerization. This stabilization may disrupt the function of proteins like KIF18B that regulate microtubule dynamics.

Vinblastine

865-21-4sc-491749
sc-491749A
sc-491749B
sc-491749C
sc-491749D
10 mg
50 mg
100 mg
500 mg
1 g
$100.00
$230.00
$450.00
$1715.00
$2900.00
4
(0)

Vinblastine binds tubulin, thereby inhibiting microtubule formation. This disruption can indirectly inhibit the expression or function of KIF18B by altering the microtubule landscape it acts upon.

Colchicine

64-86-8sc-203005
sc-203005A
sc-203005B
sc-203005C
sc-203005D
sc-203005E
1 g
5 g
50 g
100 g
500 g
1 kg
$98.00
$315.00
$2244.00
$4396.00
$17850.00
$34068.00
3
(2)

Colchicine binds to tubulin and inhibits its polymerization. By altering microtubule dynamics, it might indirectly affect KIF18B's role and its expression levels in cells.

Noscapine

128-62-1sc-219418
10 mg
$102.00
(1)

Noscapine affects tubulin's conformation and interrupts microtubule assembly. As KIF18B's primary role involves microtubules, noscapine might indirectly inhibit its expression.

Podophyllotoxin

518-28-5sc-204853
100 mg
$82.00
1
(1)

Podophyllotoxin inhibits microtubule assembly. By affecting the microtubule dynamics, it might indirectly impact the expression or function of KIF18B in cells.

Griseofulvin

126-07-8sc-202171A
sc-202171
sc-202171B
5 mg
25 mg
100 mg
$83.00
$216.00
$586.00
4
(2)

Griseofulvin disrupts microtubule functions by interacting with polymerized tubulin. This could indirectly influence the expression or role of KIF18B in microtubule-related processes.

Combrestatin A4

117048-59-6sc-204697
sc-204697A
1 mg
5 mg
$45.00
$79.00
(0)

Combretastatin binds to tubulin at the colchicine site, disrupting microtubule dynamics. By affecting this dynamics, it may indirectly inhibit the expression of KIF18B.

Estramustine

2998-57-4sc-353281
sc-353281A
100 mg
1 g
$265.00
$743.00
(0)

Estramustine binds to microtubule-associated proteins, affecting microtubule stability. This might alter the role or expression of proteins like KIF18B that regulate these dynamics.

2-Methoxyestradiol

362-07-2sc-201371
sc-201371A
10 mg
50 mg
$70.00
$282.00
6
(1)

2-Methoxyestradiol interferes with tubulin polymerization. This can potentially affect the microtubule landscape and indirectly inhibit KIF18B's expression or function.

Dolastatin 10

110417-88-4sc-507413
5 mg
$980.00
(0)

Dolastatin 10 inhibits tubulin polymerization, affecting microtubule dynamics. This can have an indirect effect on KIF18B's expression by altering its functional landscape.