Dolastatin 10 (CAS 110417-88-4)
Alternate Names:
Dolastatin-10 Dolostatin 10 CHEBI:67357
CAS Number:
110417-88-4
Molecular Weight:
785.10
Molecular Formula:
C42H68N6O6S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Dolastatin 10 (CAS 110417-88-4) References
- Activity of dolastatin 10 against small-cell lung cancer in vitro and in vivo: induction of apoptosis and bcl-2 modification. | Kalemkerian, GP., et al. 1999. Cancer Chemother Pharmacol. 43: 507-15. PMID: 10321512
- Sustained intracellular retention of dolastatin 10 causes its potent antimitotic activity. | Verdier-Pinard, P., et al. 2000. Mol Pharmacol. 57: 180-7. PMID: 10617693
- Dolastatin-10 in metastatic melanoma: a phase II and pharmokinetic trial of the California Cancer Consortium. | Margolin, K., et al. 2001. Invest New Drugs. 19: 335-40. PMID: 11561695
- Brentuximab vedotin. | . 2011. Drugs R D. 11: 85-95. PMID: 21410298
- Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain. | Bai, R., et al. 1990. Biochem Pharmacol. 39: 1941-9. PMID: 2353935
- Synthesis and evaluation of novel dolastatin 10 derivatives for versatile conjugations. | Yokosaka, S., et al. 2018. Bioorg Med Chem. 26: 1643-1652. PMID: 29454703
- Marine Antitumor Peptide Dolastatin 10: Biological Activity, Structural Modification and Synthetic Chemistry. | Gao, G., et al. 2021. Mar Drugs. 19: PMID: 34202685
- Discovery of Dolastatinol: A Synthetic Analog of Dolastatin 10 and Low Nanomolar Inhibitor of Tubulin Polymerization. | Gutman, H., et al. 2021. ACS Med Chem Lett. 12: 1596-1604. PMID: 34676042
- Discovery and Development of Dolastatin 10-Derived Antibody Drug Conjugate Anticancer Drugs. | Singh, SB. 2022. J Nat Prod. 85: 666-687. PMID: 35072477
- Biosynthesis of Dolastatin 10 in Marine Cyanobacteria, a Prototype for Multiple Approved Cancer Drugs. | Kallifidas, D., et al. 2024. Org Lett. 26: 1321-1325. PMID: 38330916
- Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions. | Bai, R., et al. 1995. Mol Pharmacol. 47: 965-76. PMID: 7746283
Inhibitor of:
α1b Tubulin, β Tubulin, β-Tubulin, β5 Tubulin, ε Tubulin, 1700019B03Rik, C19orf71, C9orf116, CAMSAP3, Dynlt1b, HOOK1, LAPSER1, MAP1D, MAP7D3, MFAP1B, MITD1, mKIAA1853, Odf2L, Syntaxin 3, TBCD, and TTLL12.Activator of:
β3 Tubulin, Microtubule Marker, NEDD1, and TPX2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dolastatin 10, 5 mg | sc-507413 | 5 mg | $980.00 |