Combrestatin A4 CAS: 117048-59-6
MF: C18H20O5
MW: 316.35
A potent inhibitor of tubulin polymerization.

Combrestatin A4 (CAS 117048-59-6)

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Synonym: CA4; CRC 87-09
Application: A potent inhibitor of tubulin polymerization
CAS Number: 117048-59-6
Molecular Weight: 316.35
Molecular Formula: C18H20O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Combrestatin A4 (CA4) is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. CA4 was shown to impede tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma), and MCF-7 (breast cancer) with IC50 values of 2.16, 5.20, 3.46, and 18.47 nM, respectively. CA4 inhibits tubulin polymerization with an IC50 value of 2.2 μM. Combrestatin A4 is an inhibitor of β Tubulin.


1 Sun, L., Vasilevich, N.I., Fuselier, J.A., et al. Abilities of 3,4-diarylfuran-2-one analogs of combretastatin A-4 to inhibit both proliferation of tumor cell lines and growth of relevant tumors in nude mice. Anticancer Res 24 179-186 (2004). 2 Dey, P. Chromatin remodeling, cancer and chemotherapy. Current Medicinal Chemistry 13 2909-2919 (2006).

Physical State :
Solubility :
Soluble in DMSO (100 mM), ethanol (100 mM), DMF (~20 mg/ml), chloroform, and water (0.1 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
114-116° C
Boiling Point :
~490.3° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
IMR32: IC50 = 2.16 nM (neuroblastoma); CFPAC-1: IC50 = 3.46 nM (pancreatic carcinoma); Hs746T: IC50 = 5.20 nM (gastric carcinoma); MCF-7: IC50 = 18.47 nM (breast cancer); Tubulin polymerization: IC50 = 2.2 µM
Ki Data :
Tubulin: Ki= 3 nM (human); Tubulin beta chain: Ki= 180 nM (bovine)
pK Values :
pKa: 9.65 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 2494
MDL Number :

Download SDS (MSDS)

Certificate of Analysis

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