Combrestatin A4 CAS: 117048-59-6
MF: C18H20O5
MW: 316.35
A potent inhibitor of tubulin polymerization.

Combrestatin A4 (CAS 117048-59-6)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 102ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: CA4; CRC 87-09
Application: A potent inhibitor of tubulin polymerization
CAS Number: 117048-59-6
Molecular Weight: 316.35
Molecular Formula: C18H20O5
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Combrestatin A4 (CA4) is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. CA4 was shown to impede tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma), and MCF-7 (breast cancer) with IC50 values of 2.16, 5.20, 3.46, and 18.47 nM, respectively. CA4 inhibits tubulin polymerization with an IC50 value of 2.2 μM. Combrestatin A4 is an inhibitor of β Tubulin.


References

1 Sun, L., Vasilevich, N.I., Fuselier, J.A., et al. Abilities of 3,4-diarylfuran-2-one analogs of combretastatin A-4 to inhibit both proliferation of tumor cell lines and growth of relevant tumors in nude mice. Anticancer Res 24 179-186 (2004). 2 Dey, P. Chromatin remodeling, cancer and chemotherapy. Current Medicinal Chemistry 13 2909-2919 (2006).

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), ethanol (100 mM), DMF (~20 mg/ml), chloroform, and water (0.1 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
114-116° C
Boiling Point :
~490.3° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
IMR32: IC50 = 2.16 nM (neuroblastoma); CFPAC-1: IC50 = 3.46 nM (pancreatic carcinoma); Hs746T: IC50 = 5.20 nM (gastric carcinoma); MCF-7: IC50 = 18.47 nM (breast cancer); Tubulin polymerization: IC50 = 2.2 µM
Ki Data :
Tubulin: Ki= 3 nM (human); Tubulin beta chain: Ki= 180 nM (bovine)
pK Values :
pKa: 9.65 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
PubChem CID :
5351344
Merck Index :
14: 2494
MDL Number :
MFCD03453309
SMILES :
COC1=C(C=C(C=C1)C=CC2=CC(=C(C(=C2)OC)OC)OC)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 139ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 11ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.