KIAA1683 Activators
The identification of activators for IQ motif-containing proteins, such as IQCN, requires a keen understanding of calcium signaling, given the inherent connection of IQ motifs to calcium binding. Many of the chemicals highlighted are known to modulate cellular calcium levels, indirectly influencing proteins with IQ motifs. Calcium ionophores like A23187, and SERCA pump such as Thapsigargin, act by elevating intracellular calcium levels. When calcium levels are elevated, the interactions between calmodulin and proteins with IQ motifs can be enhanced, influencing the modulation or activation of IQCN within cellular processes.
Furthermore, several calcium channel blockers, such as Nitrendipine, Nifedipine, and Verapamil, serve to modulate calcium influx, thereby indirectly impacting the calcium-calmodulin system. By doing so, these chemicals influence the interactions of calmodulin with proteins like IQCN. Additionally, compounds like PMA and OAG, known to activate protein kinase C (PKC), indirectly affect intracellular calcium dynamics. When PKC is activated, there can be a consequential increase in calcium within the cell, again reinforcing the central theme of calcium-calmodulin interaction being paramount for the function and modulation of IQ motif-containing proteins like IQCN. Through an intricate dance of cellular signaling modulation, these chemicals set the stage for proteins like IQCN to perform their designated functions optimally.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium ionophore that can increase intracellular calcium levels. Higher calcium concentrations can promote calmodulin binding to proteins with IQ motifs, like IQCN, thus potentially supporting its activation or modulation in cellular processes related to calcium signaling. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
Chelates extracellular calcium, causing an increase in intracellular calcium levels. The elevation in calcium can facilitate interactions of calmodulin with proteins containing IQ motifs, indirectly affecting the modulation of IQCN in the cell. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC). PKC can lead to increased intracellular calcium, thus potentially influencing calmodulin binding to IQCN and modulating its role within the cell. | ||||||
Nitrendipine | 39562-70-4 | sc-201466 sc-201466A sc-201466B | 50 mg 100 mg 500 mg | $107.00 $157.00 $449.00 | 6 | |
L-type calcium channel blocker. By modulating calcium influx, it can indirectly impact the calcium-calmodulin system and hence the activation or modulation of proteins with IQ motifs like IQCN. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Blocks L-type calcium channels, influencing calcium influx. Such modulation can impact the interactions of calmodulin with proteins like IQCN that have IQ motifs, potentially supporting their role in cellular processes linked to calcium signaling. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
SERCA pump inhibitor that elevates intracellular calcium levels. The elevated calcium can increase calmodulin interactions with proteins like IQCN, potentially affecting its cellular role. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $219.00 $765.00 | 19 | |
Modifies calcium release from the endoplasmic reticulum. Changes in calcium levels can influence IQ motif-containing proteins like IQCN through altered calmodulin interactions. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Inhibits ryanodine receptors, modulating calcium release. This modulation can indirectly affect the function of proteins like IQCN by impacting the calcium-calmodulin system. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
L-type calcium channel activator, influencing calcium dynamics. Changes in calcium can impact IQ motif-containing proteins, potentially modulating the activity of IQCN through altered calmodulin interactions. | ||||||
1-Oleoyl-2-acetyl-sn-glycerol (OAG) | 86390-77-4 | sc-200417 sc-200417A | 10 mg 50 mg | $117.00 $444.00 | 1 | |
Diacylglycerol analog that activates PKC. PKC activation can increase intracellular calcium, potentially supporting calmodulin interactions with IQCN, thus modulating its cellular role. | ||||||