Keratin 75 Inhibitors
Keratin 75 inhibitors constitute a specialized chemical class designed to selectively target and modulate the function of Keratin 75 (KRT75), a protein belonging to the keratin family. Keratins are structural proteins that form the foundation of hair, nails, and the outer layer of the skin. KRT75, specifically, is expressed in the hair follicles and plays a role in maintaining the structural integrity of the hair shaft. The inhibitors developed for Keratin 75 are meticulously crafted to interact with the specific molecular structure of this keratin variant, with the aim of disrupting its normal interactions within the cellular milieu and potentially influencing the structural characteristics of hair fibers.
The molecular architecture of Keratin 75 inhibitors is precisely tailored to engage with specific binding sites on the protein, inducing changes in its conformation and dynamics. This interaction holds the potential to impact the protein's role in hair development and maintenance. In laboratory research, these inhibitors serve as valuable tools, allowing scientists to explore the nuanced functions of Keratin 75 in the context of hair biology. By manipulating the function of KRT75, researchers aim to unravel the intricate mechanisms governing hair structure and development, contributing to a deeper understanding of the role of keratins in the maintenance of integumentary tissues. The study of Keratin 75 inhibitors stands at the forefront of advancing our comprehension of the molecular processes involved in hair biology and the maintenance of the integumentary system.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that could alter the epigenetic state of the KRT75 gene, potentially reducing its expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A metabolite of vitamin A that regulates gene expression and epithelial cell growth, potentially affecting KRT75 expression. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
An immunosuppressant that can affect T-cell function and cytokine production, which might indirectly influence KRT75 expression. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Inhibits ribonucleotide reductase, affecting DNA synthesis and potentially cell differentiation and KRT75 expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
A histone deacetylase inhibitor that can change chromatin structure and gene expression, possibly affecting KRT75. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Flavonoid that can modulate various signaling pathways, potentially altering keratinocyte function and KRT75 expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonol that may affect transcription factor activity and modulate gene expression, including that of KRT75. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that can affect cell growth and protein synthesis, potentially influencing KRT75 expression. | ||||||
13-cis-Retinoic acid | 4759-48-2 | sc-205568 sc-205568A | 100 mg 250 mg | $75.00 $120.00 | 8 | |
A synthetic retinoid that alters gene expression and keratinization, which could affect KRT75 expression. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $109.00 | 3 | |
A diuretic with antiandrogenic properties that might influence hormonal regulation of KRT75 expression. | ||||||