Date published: 2025-9-9

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KCTD11 Inhibitors

KCTD11 inhibitors are compounds that influence the activity of KCTD11 through indirect modulation of related signaling pathways, primarily the Notch signaling pathway. KCTD11, being a protein that counteracts or is inversely related to Notch pathway activation, can be indirectly activated by compounds that inhibit Notch signaling. γ-Secretase inhibitors like DAPT, LY411575, RO4929097, MK-0752, DBZ, and PF-03084014 are key in this context. They inhibit the Notch pathway, which could lead to compensatory cellular mechanisms that indirectly enhance KCTD11's activity. This enhancement stems from the role KCTD11 may play in processes that are inversely regulated by Notch signaling. Additionally, natural compounds such as Curcumin, Resveratrol, Sulforaphane, Quercetin, Genistein, and EGCG, known for their broad effects on various signaling pathways, could also play a role in modulating KCTD11 activity. These compounds can influence cellular signaling networks, including pathways that intersect with Notch signaling. This intersection provides a basis for the indirect inhibition of KCTD11, as changes in these signaling pathways could lead to altered cellular contexts where KCTD11's role becomes more prominent.

Items 1 to 10 of 11 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

DAPT

208255-80-5sc-201315
sc-201315A
sc-201315B
sc-201315C
5 mg
25 mg
100 mg
1 g
$99.00
$335.00
$836.00
$2099.00
47
(3)

DAPT is a γ-secretase inhibitor, impacting Notch signaling. By inhibiting Notch signaling, DAPT could lead to compensatory mechanisms that might indirectly activate KCTD11, as KCTD11 is implicated in processes inversely related to Notch pathway activation.

RO-4929097

847925-91-1sc-364602
sc-364602A
10 mg
50 mg
$430.00
$1389.00
1
(1)

RO4929097 is a γ-secretase inhibitor that affects Notch signaling. This inhibition might lead to indirect activation of KCTD11, considering its potential role in pathways counteracting Notch signaling effects.

MK-0752

471905-41-6sc-364534
sc-364534A
10 mg
50 mg
$592.00
$1550.00
(1)

MK-0752, a γ-secretase inhibitor, can modulate Notch signaling. Its influence on Notch signaling could lead to an indirect activation of KCTD11 through altered cellular signaling mechanisms.

Dibenzazepine (Deshydroxy LY 411575)

209984-56-5sc-207554
sc-207554A
2 mg
5 mg
$100.00
$260.00
4
(1)

DBZ is a potent γ-secretase inhibitor. By inhibiting Notch signaling, DBZ might indirectly activate KCTD11, particularly in cellular contexts where KCTD11 is involved in Notch-opposing pathways.

PF-3084014

1290543-63-3sc-507501
5 mg
$130.00
(0)

PF-03084014, another γ-secretase inhibitor, can affect Notch signaling. This could lead to an indirect activation of KCTD11, especially in systems where KCTD11 functions are inversely related to Notch pathway activation.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

Curcumin affects multiple signaling pathways and could modulate Notch signaling indirectly. This modulation might activate KCTD11, considering KCTD11's potential role in Notch-regulated processes.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

Resveratrol impacts various signaling pathways, including sirtuins and AMPK, which can intersect with Notch signaling. This intersection might indirectly lead to KCTD11 activation due to its role in counterbalancing Notch activity.

D,L-Sulforaphane

4478-93-7sc-207495A
sc-207495B
sc-207495C
sc-207495
sc-207495E
sc-207495D
5 mg
10 mg
25 mg
1 g
10 g
250 mg
$150.00
$286.00
$479.00
$1299.00
$8299.00
$915.00
22
(1)

Sulforaphane, a Nrf2 activator, can influence various cellular pathways, potentially affecting Notch signaling. This influence might indirectly activate KCTD11 by altering the cellular signaling milieu.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$108.00
$245.00
$918.00
$49.00
33
(2)

Quercetin affects multiple signaling pathways and could indirectly modulate Notch signaling. This modulation might lead to KCTD11 activation, considering its involvement in pathways that are inversely regulated by Notch.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$26.00
$92.00
$120.00
$310.00
$500.00
$908.00
$1821.00
46
(1)

Genistein, a tyrosine kinase inhibitor, can influence several signaling pathways. Its effects might lead to indirect activation of KCTD11, especially in contexts where KCTD11 function is related to pathways influenced by tyrosine kinase activity.