KCNMB3 Activators
Chemical activators of KCNMB3, known as the calcium-activated potassium channel subunit alpha-1, encompass a range of compounds that modulate calcium signaling pathways. These activators typically do not interact directly with the channel but influence its activity by altering the intracellular calcium concentration, which is the primary regulator of KCNMB3. Several of these chemicals are classified as L-type calcium channel modulators. For instance, Bay K 8644 and dihydropyridine derivatives exert their effect by directly stimulating the influx of calcium through these channels, thus facilitating the activation of KCNMB3.
Another category of activators includes inhibitors of calcium reuptake mechanisms, such as cyclopiazonic acid and CGP 37157, which inhibit the SERCA and mitochondrial Na+/Ca2+ exchanger, respectively. This inhibition results in an increased cytosolic calcium concentration, indirectly activating KCNMB3. Similarly, compounds like SKF 96365, which inhibit receptor-mediated calcium entry, and various calcium channel blockers like nicardipine and amlodipine, may lead to compensatory cellular responses that elevate intracellular calcium levels, thereby influencing KCNMB3 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
An inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA), leading to increased cytosolic calcium concentrations and potential activation of KCNMB3. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
A calcium channel activator that specifically targets L-type calcium channels, enhancing calcium influx and potentially increasing KCNMB3 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
The main catechin found in green tea, which has been shown to increase intracellular calcium levels, potentially affecting KCNMB3 activity. | ||||||
FPL-64176 | 120934-96-5 | sc-201491 | 5 mg | $83.00 | 1 | |
A calcium channel activator that increases intracellular calcium, potentially leading to the activation of KCNMB3. | ||||||
CGP 37157 | 75450-34-9 | sc-202097 sc-202097A | 5 mg 25 mg | $115.00 $463.00 | 3 | |
An inhibitor of the mitochondrial Na+/Ca2+ exchanger, potentially increasing intracellular calcium concentration and thereby activating KCNMB3. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
A non-selective inhibitor of receptor-mediated calcium entry and voltage-gated calcium channels, which can modulate calcium signaling and possibly activate KCNMB3. | ||||||
Isradipine | 75695-93-1 | sc-201467 sc-201467A | 10 mg 50 mg | $88.00 $324.00 | 1 | |
An L-type calcium channel blocker with vasodilatory activity that can lead to compensatory cellular mechanisms, indirectly affecting calcium levels and possibly KCNMB3 activation. | ||||||
Nicardipine hydrochloride | 54527-84-3 | sc-202731 sc-202731A | 1 g 5 g | $33.00 $83.00 | 5 | |
Another L-type calcium channel blocker that through feedback mechanisms can affect intracellular calcium and thus influence KCNMB3 activity. | ||||||
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $74.00 $166.00 | 2 | |
A long-acting calcium channel blocker that can influence intracellular calcium homeostasis and indirectly affect KCNMB3 activity. | ||||||
Nitrendipine | 39562-70-4 | sc-201466 sc-201466A sc-201466B | 50 mg 100 mg 500 mg | $109.00 $160.00 $458.00 | 6 | |
L-type calcium channel blocker that may lead to altered intracellular calcium signaling and have an indirect effect on KCNMB3 activation. | ||||||