karyopherin β1 Activators
Karyopherin β1 activators are a class of molecules that play a crucial role in regulating nucleocytoplasmic transport within eukaryotic cells. These compounds primarily target the karyopherin β1 protein, also known as importin β1, which is a member of the karyopherin family of nuclear transport receptors. Karyopherins are responsible for shuttling various proteins and macromolecules between the cytoplasm and the nucleus, a fundamental process in cellular homeostasis. Karyopherin β1, in particular, is a central player in this transport system, facilitating the import of proteins bearing a nuclear localization signal (NLS) into the nucleus and exporting proteins with a nuclear export signal (NES) to the cytoplasm.
Karyopherin β1 activators function by modulating the activity of karyopherin β1, enhancing its capacity to interact with cargo proteins and facilitate their translocation across the nuclear envelope. These activators typically work through allosteric mechanisms, inducing conformational changes in karyopherin β1 that increase its affinity for NLS-bearing cargo molecules. By doing so, they promote the efficient and selective import of specific proteins into the nucleus, contributing to the precise regulation of gene expression, signal transduction, and other critical cellular processes. Understanding the molecular mechanisms by which karyopherin β1 activators operate has provided valuable insights into the fundamental biology of nucleocytoplasmic transport and has the potential to influence various fields of cell biology and molecular research.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a natural phenol found in certain plants. It has been shown to upregulate the expression of various proteins through its antioxidant and anti-inflammatory properties, potentially including karyopherin β1. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a bright yellow chemical produced by Curcuma longa plants. It has anti-inflammatory effects and modulates various signaling pathways, potentially influencing the expression of karyopherin β1. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Found in cruciferous vegetables, sulforaphane is known for its antioxidant properties. It may influence the expression of proteins related to cellular protection and stress response, including karyopherin β1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is the most abundant catechin in tea and has antioxidant properties. It is thought to regulate protein expression and cellular pathways, possibly including karyopherin β1. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid found in many fruits and vegetables. It has antioxidant effects and modulates signaling pathways, which could impact the expression of proteins like karyopherin β1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
A metabolite of Vitamin A, retinoic acid influences cell growth and differentiation. It regulates gene expression and could potentially impact karyopherin β1 levels. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $61.00 | 1 | |
Selenium is an essential trace element that is crucial for the proper functioning of the body. It plays a role in antioxidant defense and protein synthesis, potentially affecting karyopherin β1 expression. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is an essential trace element known to play a role in cellular metabolism and protein synthesis. Its involvement in gene expression regulation could influence karyopherin β1 levels. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium is a chemical element that has been shown to influence various cellular processes, including gene expression and signal transduction, possibly affecting karyopherin β1 expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a short-chain fatty acid with histone deacetylase inhibitory activity. It can influence gene expression and has the potential to modulate karyopherin β1 levels. | ||||||