κ-Actin Inhibitors constitute a specialized class of chemical compounds designed to selectively impede the activity of κ-actin, a variant of the actin protein. Actin proteins are essential components of the cytoskeleton, contributing to cellular structure, motility, and intracellular transport. κ-Actin, a specific isoform within the actin family, exhibits unique structural and functional features. The development of inhibitors targeting κ-actin is crucial for scientific investigations, providing researchers with specific tools to explore the molecular functions and regulatory roles associated with this particular actin variant.
The synthesis and optimization of κ-Actin Inhibitors require a detailed understanding of the isoform's structural characteristics and its interactions within cellular pathways. These inhibitors are meticulously designed for specificity, aiming to selectively bind to key regions of κ-actin and interfere with its normal cytoskeletal functions. By employing κ-Actin Inhibitors in experimental settings, researchers can explore the consequences of isoform-specific inhibition on cellular processes, shedding light on the specific substrates and molecular pathways influenced by κ-actin. The study of κ-Actin Inhibitors contributes to the broader exploration of cytoskeletal dynamics, providing insights into the intricate molecular machinery that underlies fundamental cellular functions related to cell shape, movement, and structural integrity, with a specific focus on the unique properties of the κ-actin isoform.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to DNA, inhibiting transcription and preventing the synthesis of κ-Actin mRNA. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide disrupts protein synthesis, leading to a reduction in κ-Actin expression by inhibiting translation. | ||||||
Puromycin dihydrochloride | 58-58-2 | sc-108071 sc-108071B sc-108071C sc-108071A | 25 mg 250 mg 1 g 50 mg | $42.00 $214.00 $832.00 $66.00 | 394 | |
Puromycin induces premature termination of protein synthesis, impacting translation and lowering κ-Actin levels. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin inhibits bacterial RNA polymerase, indirectly suppressing κ-Actin expression by interfering with transcription. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin hinders protein synthesis by blocking peptidyl transferase activity, leading to reduced κ-Actin synthesis. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $101.00 | 5 | |
Cordycepin interferes with mRNA synthesis, impacting transcription and contributing to the downregulation of κ-Actin. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $69.00 $266.00 | 8 | |
Mycophenolic acid inhibits inosine monophosphate dehydrogenase, indirectly affecting κ-Actin expression by disrupting purine synthesis. | ||||||
Blasticidin S Hydrochloride | 3513-03-9 | sc-204655A sc-204655 | 25 mg 100 mg | $367.00 $520.00 | 20 | |
Blasticidin S induces premature termination during translation, inhibiting protein synthesis and reducing κ-Actin levels. | ||||||
Ellipticine | 519-23-3 | sc-200878 sc-200878A | 10 mg 50 mg | $145.00 $569.00 | 4 | |
Ellipticine intercalates into DNA, disrupting DNA structure and inhibiting transcription, leading to decreased κ-Actin mRNA. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil interferes with RNA synthesis, affecting the expression of κ-Actin by disrupting the production of mRNA. | ||||||