K-cadherin Activators
Cadherins are calcium-dependent adhesion molecules found on the surface of many types of cells. They are crucial for the appropriate functioning of cells because they mediate cell-to-cell adhesion, ensuring that cells within tissues are held together. Structurally, cadherins are transmembrane proteins with a series of extracellular cadherin repeats, a single transmembrane domain, and a cytoplasmic domain that can interact with various intracellular partners. One of the unique features of cadherins is their ability to bind calcium, which is essential for their adhesive function. In the absence of calcium, cadherin structures become unstable, leading to a loss of cell adhesion.
The diversity of the cadherin family is vast, with many different cadherins being identified, each having its tissue-specific expression pattern and function. This includes E-cadherin (epithelial), N-cadherin (neural), and P-cadherin (placental), among others. Given the variety and specificity of cadherins, it is conceivable that researchers could investigate molecules or compounds that might modulate the activity of specific cadherin types. If K-cadherin Activators were to emerge or be identified in future research, they would likely represent molecules or compounds that enhance the activity or expression of K-cadherin. This enhancement could have profound implications for cell adhesion and tissue organization in areas where K-cadherin is naturally expressed.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can influence cell differentiation and proliferation. Through its impact on various signaling pathways, it might induce the expression of differentiation-related proteins, including cadherins such as K-cadherin. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3, when metabolized to its active form, can modulate gene expression. This might involve the promotion of K-cadherin expression in certain cellular contexts. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
As a glucocorticoid, dexamethasone can regulate numerous genes. Its anti-inflammatory effects might impact pathways that modulate K-cadherin expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels. This can modulate a variety of cellular pathways, potentially leading to increased K-cadherin expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
This compound is a DNA methyltransferase inhibitor and can reactivate genes silenced by DNA methylation. Its action might lead to the re-expression of K-cadherin in certain contexts. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
As a histone deacetylase inhibitor, Trichostatin A can influence gene expression by changing chromatin structure. This could potentially lead to the induction of K-cadherin expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a phytoestrogen and tyrosine kinase inhibitor. Its actions on cell signaling pathways might promote the expression of K-cadherin. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, found in cruciferous vegetables, has been shown to influence gene expression via the NRF2 pathway. This might indirectly lead to enhanced K-cadherin expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol can modulate various cellular pathways, including those related to stress response and survival. It might influence the expression of cadherins, including K-cadherin. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, from turmeric, can affect a range of cellular processes. Its anti-inflammatory and antioxidative properties might modulate pathways leading to K-cadherin expression. | ||||||