JRK Activators
JRK, also known as Jerky homolog-like (JRK/JH8), is a nuclear protein that has been associated with the regulation of gene expression and the maintenance of genomic stability. It is encoded by the JRK gene and is expressed in various tissues, with a notable presence in the brain. JRK is characterized by the presence of a DNA-binding domain, suggesting its role as a transcriptional regulator.
The protein has been implicated in epilepsy and seizures; in fact, mutations in the JRK gene have been linked to idiopathic generalized epilepsy. This connection indicates that JRK might play an essential role in neuronal excitability and synaptic function. The exact mechanisms by which JRK contributes to the regulation of neural networks and the prevention of seizure activity are not fully understood, but it is believed that JRK might influence the expression of genes that are critical for the proper functioning of neurons.In addition to its role in the nervous system, JRK is involved in cellular responses to DNA damage. It is thought to participate in the complex network of DNA repair and cell cycle control, thereby safeguarding genomic integrity. Proper function of JRK is crucial for preventing the accumulation of DNA errors, which can lead to cell death or uncontrolled cell proliferation, as seen in cancerous growths.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels in cells, which can lead to the activation of PKA. PKA may phosphorylate transcription factors that enhance the transcription of the JRK gene, thus increasing JRK protein levels. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration. Elevated calcium levels can activate signaling pathways, such as calcineurin/NFAT, which could enhance the transcription and activity of JRK. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a PKC activator that can modulate various cellular pathways. PKC activation may lead to alterations in transcription factor activity that could upregulate JRK expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid acts on nuclear receptors to regulate gene expression. It may enhance the transcription of genes, including JRK, by binding to retinoic acid-responsive elements in their promoters. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a kinase inhibitor that may indirectly increase JRK protein levels by inhibiting kinases that negatively regulate pathways leading to JRK activation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that can result in DNA demethylation, potentially leading to the upregulation of JRK expression if the JRK gene promoter is demethylated. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA is a histone deacetylase inhibitor that can increase the acetylation of histones, leading to a more relaxed chromatin structure and potentially enhancing the transcription of the JRK gene. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3 interacts with its nuclear receptor, influencing gene expression. It could enhance JRK transcription by affecting regulatory elements within the JRK gene promoter. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor that can cause hyperacetylation of histones, potentially leading to increased transcription of JRK by altering the chromatin state. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that may indirectly enhance JRK activity by modulating downstream signaling pathways, potentially leading to changes in transcription factor activity and JRK expression. | ||||||