ITI-H5L Inhibitors
Inhibitors of ITI-H5L function by disrupting specific signaling pathways and enzymatic activities that are crucial for the protein's role in cellular processes. For instance, some compounds target ATP binding sites of kinases, leading to the inactivation of kinase-driven processes integral to the protein's activity. By inhibiting kinases that ITI-H5L relies on for activating downstream signaling involved in cell growth and proliferation, these inhibitors effectively reduce the protein's ability to influence these critical cellular functions. Other inhibitors act more upstream, targeting the mTOR signaling pathway, which is essential for the protein's functions in cell growth and proliferation, resulting in a blockade of the necessary downstream signaling.
Moreover, the activity of ITI-H5L is also controlled by PI3K/AKT signaling pathways, where the presence of certain compounds leads to a prevention of AKT activation, thereby hampering the protein's involvement in cell survival and metabolic processes. Inhibitors that focus on the MAPK/ERK pathway can indirectly decrease the activity of ITI-H5L related to cell differentiation by preventing the activation of MEK1/2. Additional inhibitors that disrupt the JNK pathway, which ITI-H5L may be engaged in during cellular stress responses, contribute to the modulation of the protein's functional capacity.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
This compound is a histone deacetylase inhibitor that alters the chromatin structure, which can lead to the repression of gene expression. In the context of ITI-H5L, the altered chromatin state prevents the transcription of genes that are crucial for ITI-H5L's functional activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
As an mTOR inhibitor, it interrupts the mTOR signaling pathway. Since ITI-H5L is involved in cell growth and proliferation through this pathway, the inhibition of mTOR leads to a decrease in ITI-H5L-mediated signaling events. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor that targets a wide range of kinases involved in the cell cycle. It can indirectly inhibit ITI-H5L by preventing phosphorylation events that are necessary for ITI-H5L's activation or stability. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that blocks the PI3K/AKT pathway. By cutting off this route, it prevents the phosphorylation and subsequent activation of downstream proteins that are essential for ITI-H5L's role in cell survival and metabolism. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
This compound is also a PI3K inhibitor, leading to the indirect inhibition of ITI-H5L by shutting down the PI3K/AKT pathway which is crucial for ITI-H5L's activity in cellular processes. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
This compound inhibits MEK1/2, which are part of the MAPK/ERK pathway. Since ITI-H5L function is tied to MAPK/ERK signaling, inhibiting this pathway with U0126 would lead to reduced ITI-H5L activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, SP600125 blocks the JNK signaling pathway. ITI-H5L, being involved in the response to stress stimuli that act through JNK, is indirectly inhibited by this compound. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAPK inhibitor that impedes the p38 MAPK pathway. ITI-H5L's role in inflammation and stress response is compromised when SB 203580 is used to inhibit this pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
This MEK inhibitor specifically blocks the MAPK/ERK pathway, leading to the downregulation of ITI-H5L activity, which is reliant on this pathway for its regulation and function. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that prevents the degradation of proteins tagged for destruction. This indirect action can lead to the accumulation of regulatory proteins that negatively affect ITI-H5L's activity. | ||||||