ISLR Activators
ISLR activators encompass a variety of chemical compounds that enhance the functional activity of ISLR through different signaling pathways, particularly in the context of cellular adhesion and migration. Forskolin, for instance, indirectly promotes ISLR activity by increasing cAMP levels, which activate PKA; this kinase can phosphorylate proteins that interact with ISLR, thereby influencing its signaling role in cell adhesion. Similarly, Sphingosine-1-phosphate engages its G-protein-coupled receptors to initiate signaling cascades that can enhance cellular processes involving ISLR. Epigallocatechin gallate, by functioning as a kinase inhibitor, may boost ISLR-mediated adhesion signaling by attenuating competitive pathways, and LY294002, as a PI3K inhibitor, can also tilt intracellular signaling in favor of ISLR's role in adhesionand migration. PD 98059, an MEK inhibitor, can complement these effects by dampening the MAPK/ERK pathway, thus potentially augmenting ISLR signaling indirectly. Calpeptin's action as a calpain inhibitor and Thapsigargin's role in increasing intracellular calcium both work to solidify cellular structures and promote signaling pathways that can enhance ISLR's functional activity.
Additionally, PMA activates PKC, which may phosphorylate substrates integral to ISLR's role in cellular adhesion, while Staurosporine, despite its broad kinase inhibition profile, could selectively enhance ISLR signaling by inhibiting kinases that otherwise negatively regulate ISLR pathways. W-7's inhibition of calmodulin-dependent processes and BAPTA-AM's modulation of intracellular calcium can further tilt the balance of cellular signaling towards ISLR activation. Anisomycin, through its induction of stress-activated protein kinases, may also contribute to the enhancement of ISLR's role in the complex orchestration of cellular adhesion and migration, illustrating a network of indirect activators that converge on the modulation of ISLR activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, which increases intracellular cAMP levels, leading to the activation of PKA. PKA can then phosphorylate substrates that may interact with ISLR, thereby potentially enhancing its signaling capacity in cell adhesion and migration processes. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P activates S1P receptors which are coupled to G-proteins, leading to downstream signaling events that can modulate cellular adhesion and migration, processes in which ISLR is implicated. This may result in an enhanced functional activity of ISLR. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG acts as a kinase inhibitor, which can lead to the upregulation of adhesion pathways. Since ISLR is involved in cell adhesion, EGCG could enhance ISLR-mediated adhesion signaling by inhibiting competitive signaling pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor, which may shift the balance of intracellular signaling towards pathways that enhance ISLR's role in cellular processes like adhesion. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 is an MEK inhibitor, which can lead to the modulation of MAPK/ERK pathway. The inhibition of this pathway may enhance ISLR-mediated signaling by reducing competition from the MAPK/ERK pathway in cellular adhesion. | ||||||
Calpeptin | 117591-20-5 | sc-202516 sc-202516A | 10 mg 50 mg | $121.00 $456.00 | 28 | |
Calpeptin is a calpain inhibitor, which may prevent the cleavage of cellular substrates. This inhibition can stabilize the cellular architecture and enhance the signaling functionality of ISLR in adhesion. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor, leading to an increase in cytosolic calcium levels. Elevated calcium can activate signaling pathways that enhance the role of ISLR in cell adhesion and migration. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a PKC activator, which can phosphorylate various substrates involved in cellular adhesion, potentially enhancing the signaling processes that involve ISLR. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor, which could lead to selective activation of ISLR-related pathways by reducing the activity of kinases that negatively regulate ISLR's role in cellular processes. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is an intracellular calcium chelator. By modulating calcium levels, it can indirectly influence signaling pathways that enhance ISLR functionality in cell communication and adhesion. | ||||||