ISG12b Activators
Activators of ISG12b function through an array of signaling pathways and cellular processes, ultimately enhancing its activity. Through the modulation of adenylyl cyclase activity, one class of activators leads to an increase in cyclic AMP levels, thereby influencing signaling cascades that culminate in the upregulation of ISG12b. Such mechanisms are pivotal, given the protein's participation in immune response pathways, where intracellular signaling is finely tuned. Similarly, DNA methylation dynamics play a role in regulating gene expression, and compounds that inhibit DNA methyltransferases can cause hypomethylation, thus promoting the expression of genes like ISG12b. This can be achieved by the introduction of compounds that demethylate DNA, potentially enhancing the transcription and subsequent activity of ISG12b.
Additionally, certain compounds impact the transcriptional control exerted by nuclear receptors and transcription factors, which govern the expression of ISG12b. For example, agents that activate sirtuins or modulate the activity of NF-κB can indirectly increase the expression of ISG12b by influencing the transcription factors that control its gene expression. Furthermore, the inhibition of enzymes like phosphodiesterases leads to an accumulation of secondary messengers that signal for the activation of ISG12b, while the inhibition of kinases involved in inflammation and immune response pathways can result in the activation of transcription factors that upregulate ISG12b expression. Other activators operate by initiating the activation of cellular receptors that act as transcription factors, thereby modifying the expression of genes responsive to immune signals.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, resulting in increased production of cyclic AMP (cAMP), which is a second messenger involved in the regulation of various cellular responses. The elevation in cAMP levels can enhance the signaling pathways that lead to the activation of ISG12b, as ISG12b is part of the interferon-stimulated gene family and its activity is modulated by intracellular signaling cascades. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that causes hypomethylation of DNA. This demethylation can lead to the upregulation of various genes, including interferon-stimulated genes like ISG12b. By altering the epigenetic state of the DNA, 5-Azacytidine indirectly increases the activity of ISG12b by facilitating its expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, a member of the sirtuin family of proteins, which are involved in cellular stress responses. Activation of SIRT1 can lead to the deacetylation and activation of transcription factors involved in the expression of ISG12b, thereby indirectly increasing its functional activity. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $25.00 $80.00 $136.00 | 8 | |
Sodium Salicylate inhibits NF-κB, a transcription factor that regulates the expression of multiple genes, including those involved in immune responses. By modulating the activity of NF-κB, Sodium Salicylate can indirectly enhance the expression of ISG12b, which is part of the immune response gene set. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin modulates various signaling pathways, including NF-κB, which plays a role in the immune response and the expression of interferon-stimulated genes. By inhibiting NF-κB activation, Curcumin can lead to an increased expression of ISG12b, as it is part of the immune response-related genes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Inhibits DNA methyltransferases, leading to hypomethylation of DNA and potentially the upregulation of genes that are usually silenced. This can result in the activation of ISG12b expression, as demethylation of the promoter region may enhance its transcription. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin has been shown to inhibit phosphodiesterases, leading to an increase in intracellular cAMP levels. Elevated cAMP can enhance the signaling pathways that contribute to the activation of ISG12b, consistent with its role in the interferon response. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid modulates gene expression by activating retinoic acid receptors, which can act as transcription factors. Through this mechanism, Retinoic Acid could indirectly lead to the activation of ISG12b expression, as it alters the transcriptional landscape in response to immune signals. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits glycogen synthase kinase-3 (GSK-3), which is involved in a number of cellular signaling pathways including those related to inflammation and immune responses. Inhibition of GSK-3 can result in the activation of transcription factors that enhance the expression of ISG12b. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone activates the peroxisome proliferator-activated receptor gamma (PPARγ), which can lead to the transcriptional activation of various genes involved in immune responses. This can include the upregulation of ISG12b as part of the cellular response to inflammation. | ||||||