IRX1 Inhibitors
Chemical inhibitors of IRX1 can effectively impede its function through various cellular signaling pathways that are critical to the protein's role in development and maintenance of cardiac structures. Y-27632, a Rho-associated protein kinase (ROCK) inhibitor, disrupts smooth muscle cell contraction and actomyosin contractility, which are essential for the proper function of IRX1 in heart tissue formation. Similarly, SB431542 targets the TGF-β type I receptor ALK5, and by inhibiting this receptor, the TGF-β signaling pathway is disrupted. This pathway is integral to cardiac differentiation and morphogenesis, processes where IRX1 plays a crucial role. Another inhibitor, U0126, selectively inhibits MEK1/2, impairing the MAPK/ERK pathway. This pathway's inhibition can lead to functional inhibition of IRX1, given that IRX1 is involved in developmental pathways regulated by MAPK/ERK signaling.
Furthermore, LY294002 and Wortmannin both act as PI3K inhibitors, which leads to the disruption of the PI3K/Akt signaling pathway, a critical pathway for cellular proliferation and survival where IRX1 is implicated. Dorsomorphin and LDN-193189, by inhibiting AMPK and BMP type I receptors ALK2 and ALK3, respectively, interfere with BMP signaling, which is another pathway crucial for developmental processes in which IRX1 is involved. SP600125, as a JNK pathway inhibitor, and PP2, a Src family kinase inhibitor, hinder pathways involved in various cellular processes, including development, potentially leading to a functional inhibition of IRX1. Additionally, SU5402 and PD173074, as inhibitors of FGFR, block fibroblast growth factor signaling, which is important for developmental processes involving IRX1. The inhibition of these pathways can interfere with the role that IRX1 plays in these processes, leading to its functional inhibition.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A ROCK inhibitor that can lead to the relaxation of smooth muscle cells and reduce actomyosin contractility. Since IRX1 is involved in cardiovascular development, interfering with muscle contractility can indirectly inhibit IRX1 function in the development and maintenance of cardiac structures. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
An inhibitor of the TGF-β type I receptor ALK5, which when inhibited, can lead to a disruption in the TGF-β signaling pathway. IRX1, which plays a role in the development of the heart, can be functionally inhibited due to the perturbation of this pathway, as TGF-β signaling is important for cardiac differentiation and morphogenesis. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
A selective inhibitor of MEK1/2 which impairs the MAPK/ERK pathway. The MAPK/ERK pathway is involved in numerous developmental processes that IRX1 may be involved in, so inhibiting this pathway can lead to a functional inhibition of IRX1 in these developmental contexts. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that can disrupt the PI3K/Akt signaling pathway. Given that this pathway plays a role in cellular proliferation and survival, its inhibition can affect processes where IRX1 is a critical player, leading to its functional inhibition in such contexts. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $94.00 $348.00 | 69 | |
An AMPK inhibitor and also known as a BMP inhibitor, which can inhibit bone morphogenetic protein (BMP) signaling. IRX1, being implicated in developmental processes, could be functionally inhibited by the disruption of BMP signaling in these pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of the c-Jun N-terminal kinase (JNK), which can affect the JNK signaling pathway. Since the JNK pathway is involved in a multitude of cellular processes, including those related to development in which IRX1 is implicated, its inhibition can functionally inhibit IRX1 activity in these processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A MEK inhibitor specific to the MAPK/ERK pathway, which is involved in cell differentiation and proliferation. Inhibition of this pathway can functionally inhibit IRX1 by disrupting the signaling that contributes to the processes IRX1 regulates. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
Src family kinase inhibitor which can disrupt the Src signaling pathway. Since Src signaling is involved in various cellular processes, its inhibition may lead to functional inhibition of IRX1 by affecting the cellular milieu in which IRX1 operates. | ||||||
SU 5402 | 215543-92-3 | sc-204308 sc-204308A | 1 mg 5 mg | $62.00 $96.00 | 36 | |
An FGFR inhibitor that can block fibroblast growth factor signaling, a pathway that influences developmental processes. With FGFR signaling inhibited, the functional role of IRX1 in development can also be inhibited. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A PI3K inhibitor like LY294002, wortmannin can inhibit the PI3K/Akt pathway, which is crucial for cell survival and proliferation, potentially leading to functional inhibition of IRX1 in processes where PI3K signaling is involved. | ||||||