IRX1 Activators
IRX1 Activators encompass a diverse collection of chemical compounds that indirectly enhance the functional activity of IRX1 through distinct signaling pathways. Forskolin acts by increasing adenylate cyclase activity, which raises intracellular cAMP levels, leading to activated PKA. The phosphorylation cascade initiated by PKA may include proteins that regulate transcription factors associated with IRX1, therefore amplifying its functional role. Similarly, PMA, through PKC activation, influences transcriptional regulators upstream of IRX1, suggesting an enhancement of IRX1 function by modulating the transcriptional activity of its regulators. Cyclic AMP analogs like 8-Br-cAMP and db-cAMP sustain PKA activation, which is linked to the phosphorylation of proteins involved in the regulatory network of IRX1, thus facilitating its activity. Isoproterenol, by stimulating beta-adrenergic receptors, leads to increased cAMP and PKA activation, indirectly enhancing IRX1's functional activity by affecting its transcriptional regulation.
Additionally, calcium signaling modulators such as A23187 and Ionomycin increase intracellular calcium levels, triggering calcium-dependent kinases that can alter the activity of transcription factors regulating IRX1, thereby promoting its function. EGCG's kinase inhibitory properties might reduce inhibitory phosphorylations on transcription factors associated with IRX1, suggesting enhancement of IRX1 activity. Sildenafil, by inhibiting PDE5, sustains cAMP and cGMP levels, leading to a cascade that could enhance IRX1 function through modifications of transcription factor activities. Lithium chloride's inhibition of GSK-3 may alleviate suppression of transcriptional regulators impacting IRX1 activity. Retinoic acid, by acting on its receptors, influences gene expression patterns in a way that could support the functional activity of IRX1. Lastly, Bisindolylmaleimide I, by selectively inhibiting PKC, could shift the balance of phosphorylation events in favor of activating transcriptional regulators of IRX1, suggesting an enhancement of its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, a labdane diterpenoid, is an activator of adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels within cells. Elevated cAMP activates protein kinase A (PKA), which can then phosphorylate various proteins that interact with the transcription factors like IRX1, enhancing its functional activity within its specific gene regulatory networks. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diacylglycerol analog which activates protein kinase C (PKC). PKC plays a role in signaling pathways that can alter transcription factor activities, including factors that are upstream of IRX1. Activation of PKC can thus indirectly enhance the functional activity of IRX1 by promoting the transcriptional activity of proteins that regulate IRX1 target genes. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Br-cAMP is a cell-permeable cAMP analog that resists degradation by phosphodiesterases, leading to sustained activation of PKA. By this mechanism, 8-Br-cAMP enhances phosphorylation events that could facilitate the activity of transcription factors regulating IRX1 target genes, indirectly enhancing the functional activity of IRX1. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic sympathomimetic amine and non-selective beta-adrenergic agonist. By stimulating beta-adrenergic receptors, it leads to increased intracellular levels of cAMP and consequent activation of PKA. This can enhance the functional activity of IRX1 by augmenting the phosphorylation state of proteins associated with IRX1's transcriptional regulation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that facilitates the influx of calcium ions. Elevated intracellular calcium can activate calcium-dependent signaling pathways, some of which are known to influence the activity of transcription factors. As such, A23187 can indirectly enhance the activity of IRX1 by affecting the calcium signaling pathways that modulate transcription factor function linked to IRX1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a type of catechin found in green tea with kinase inhibitory activity. It can inhibit kinases that negatively regulate transcription factors involved in IRX1 signaling pathways, thereby potentially enhancing the functional activity of IRX1 through the reduction of inhibitory phosphorylations. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a cAMP analog that is resistant to degradation and can diffuse into cells to activate PKA. This compound can enhance the functional activity of IRX1 by sustaining elevated PKA activity and thereby influencing proteins that regulate IRX1 activity at the transcriptional level. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3 (GSK-3), a negative regulator of several transcription factors. Inhibition of GSK-3 can result in the enhanced activity of transcriptional regulators that govern the expression and functional activity of IRX1. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, activating calcium/calmodulin-dependent protein kinases (CaMKs). These kinases can modulate the activity of transcription factors that regulate the expression of IRX1, leading to enhanced function of IRX1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, acts as a ligand for retinoic acid receptors, which regulate gene expression by acting as transcription factors. Through these mechanisms, retinoic acid can enhance the functional activity of IRX1 by promoting the expression of genes that are in the regulatory network of IRX1. | ||||||