IRF-7 Inhibitors
Common IRF-7 Inhibitors include, but are not limited to Amlexanox CAS 68302-57-8, BAY 11-7082 CAS 19542-67-7, BX 795 CAS 702675-74-9, DMXAA CAS 117570-53-3 and Isoimperatorin CAS 482-45-1.
IRF-7 inhibitors belong to a specific chemical class of compounds designed to target and inhibit the activity of Interferon Regulatory Factor 7 (IRF-7). IRF-7 is a transcription factor that plays a critical role in the immune response, particularly in the regulation of type I interferon production. Upon viral infection or other immune stimuli, IRF-7 is activated and translocates to the nucleus, where it induces the expression of type I interferon genes, promoting an antiviral state in the cell and stimulating the immune response.
IRF-7 inhibitors work by specifically targeting the IRF-7 protein, interfering with its activation or nuclear translocation, and modulating its ability to induce the expression of type I interferons. By doing so, these inhibitors may regulate the antiviral response and the overall immune defense against viral infections. Research into IRF-7 and its inhibitors is ongoing to unravel their precise mechanisms of action and explore their implications in the regulation of innate immunity. The study of IRF-7 inhibitors represents an intriguing area of research, contributing to a deeper understanding of the complex network of immune signaling pathways involved in antiviral defense.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amlexanox | 68302-57-8 | sc-217630 | 10 mg | $160.00 | 2 | |
Inhibits IRF-7 activation by blocking its phosphorylation and nuclear translocation, leading to reduced interferon production and antiviral response. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Prevents the activation of IRF-7 by inhibiting the IκB kinase complex, thereby blocking IRF-7 nuclear translocation and decreasing IFN production. | ||||||
BX 795 | 702675-74-9 | sc-281689 sc-281689A sc-281689C sc-281689B sc-281689D sc-281689E | 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg | $219.00 $273.00 $331.00 $495.00 $882.00 $1489.00 | 5 | |
Inhibits IRF-7 phosphorylation and its nuclear translocation by targeting TBK1/IKKε kinases, reducing the induction of type I interferon and antiviral genes. | ||||||
DMXAA | 117570-53-3 | sc-207592 sc-207592A | 5 mg 25 mg | $129.00 $590.00 | 1 | |
Activates STING, leading to the downstream suppression of IRF-7, resulting in reduced interferon production and tumor growth inhibition. | ||||||
Isoimperatorin | 482-45-1 | sc-218607 | 10 mg | $301.00 | 1 | |
Suppresses IRF-7 and NF-κB activation, leading to decreased IFN-β production and inflammatory responses in immune cells. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $214.00 $257.00 $1775.00 $2003.00 | 34 | |
Inhibits the nuclear translocation of IRF-7 by blocking its interaction with importin-α5, reducing type I IFN production and inflammatory cytokines. | ||||||
ML 120B Dihydrochloride | 783348-36-7 (free base) | sc-487759 | 5 mg | $380.00 | ||
Targets the TBK1/IKKε kinases, inhibiting IRF-7 phosphorylation, nuclear translocation, and the subsequent production of type I interferon. | ||||||
NSC697923 | 343351-67-7 | sc-391107 sc-391107A | 1 mg 5 mg | $15.00 $52.00 | 3 | |
Disrupts IRF-7 interaction with importin-α3, preventing its nuclear translocation and reducing the production of interferon and proinflammatory cytokines. | ||||||
Pterostilbene, Pterocarpus marsupium | 537-42-8 | sc-203223 sc-203223A | 10 mg 100 mg | $211.00 $1196.00 | ||
Downregulates IRF-7 and its downstream signaling, leading to suppressed type I interferon production and decreased inflammation in immune cells. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
Targets JAK1/2 kinases and inhibits the JAK-STAT pathway downstream of IRF-7, leading to reduced interferon production and attenuation of immune responses. | ||||||