IRF-4 Activators
IRF-4 Activators encompasses a diverse group of compounds that indirectly influence the activation of the transcription factor IRF-4. These chemicals interact with various signaling pathways and cellular processes, leading to the modulation of IRF-4 activity. Some IRF-4 activators can modulate NF-κB signaling, a pathway that has crosstalk with IRF-4 regulatory mechanisms, thereby influencing IRF-4's activity in the context of immune responses.
Other compounds exert their effects by inhibiting key enzymes or signaling molecules in T cell activation and differentiation pathways, which are known to involve IRF-4. Specific kinase inhibitors alter cellular signaling in response to stress and inflammation, with downstream effects on IRF-4 activation. These chemicals can impact the activity or expression of IRF-4 by altering the cellular context or the signaling milieu, thereby indirectlymodulating IRF-4's role in gene regulation. Each of these chemicals interacts with complex intracellular signaling cascades, leading to varied effects on IRF-4 activity.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC), which can lead to the activation of downstream transcription factors, including IRF-4, in lymphocytes. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Increases intracellular calcium levels, synergizing with PMA to activate PKC and downstream signaling pathways involving IRF-4. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Modulates NF-κB signaling, which is known to cross-talk with pathways leading to IRF-4 activation in immune cells. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Influences sirtuin activity and modulates NF-κB signaling, which can contribute to the regulation of genes controlled by IRF-4. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Inhibits calcineurin, leading to altered T cell activation pathways that may increase IRF-4 activity in certain immune responses. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibits mTOR signaling, which is involved in the differentiation of Th cells that express IRF-4. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Inhibits the proteasome, leading to the accumulation of proteins that regulate IRF-4 activity, such as NF-κB. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
A histone deacetylase inhibitor that can affect chromatin remodeling and gene expression, potentially impacting IRF-4 expression levels. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Glycogen synthase kinase-3 (GSK-3) inhibitor, influencing Wnt signaling and possibly affecting IRF-4 activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels and possibly influencing pathways that regulate IRF-4 activity. | ||||||