IRF-1 Activators
Common IRF-1 Activators include, but are not limited to Lipopolysaccharide, E. coli O55:B5 CAS 93572-42-0, Retinoic Acid, all trans CAS 302-79-4, Polyinosinic acid - polycytidylic acid sodium salt, double-stranded CAS 42424-50-0, Cisplatin CAS 15663-27-1 and Curcumin CAS 458-37-7.
IRF-1 activators belong to a distinct chemical class known for their capability to modulate the activity of Interferon Regulatory Factor 1 (IRF-1), a transcription factor that plays a fundamental role in cellular responses to various stressors and immune challenges. These activators function by influencing the interactions and pathways involving IRF-1, which is intricately involved in mediating immune responses, cell growth regulation, and apoptosis. IRF-1 is an essential component of the innate immune system, coordinating the expression of numerous genes involved in antiviral defenses, inflammation, and immune cell activation. IRF-1 activators are carefully designed to target specific mechanisms or pathways associated with IRF-1, thus influencing its cellular functions and downstream effects.
The development of IRF-1 activators requires a comprehensive understanding of the structural attributes of IRF-1 and its interactions with other proteins and DNA. Researchers in this field strive to engineer molecules that facilitate the activation of IRF-1, contributing to its role in orchestrating cellular responses to external challenges. These activators often employ innovative design strategies that enhance IRF-1's functional role in gene expression and immune regulation. By gaining insights into the intricate mechanisms through which IRF-1 participates in coordinating immune responses and cellular behaviors, researchers aim to unravel its significance in fundamental biological phenomena. Ongoing advancements in molecular pharmacology and chemical synthesis drive the refinement of IRF-1 activators, offering applications across diverse scientific domains where manipulation of IRF-1-mediated processes is of interest.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
TLR ligands, such as lipopolysaccharide (LPS) and double-stranded RNA, activate immune responses by binding to TLRs. This activation can lead to the upregulation of IRF-1 as part of the innate immune response. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a derivative of vitamin A, is known to induce IRF-1 expression. It has immunomodulatory effects and can regulate the expression of several genes involved in immune responses. | ||||||
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded | 42424-50-0 | sc-204854 sc-204854A | 10 mg 100 mg | $139.00 $663.00 | 2 | |
Poly(I:C) is a synthetic analog of double-stranded RNA that mimics viral infections. It is commonly used to stimulate immune responses in experimental settings and induces IRF-1 expression. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin is a compound used to treat various cancers. It has been reported to induce IRF-1 expression, possibly contributing to its cytotoxic effects on cancer cells. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a natural compound found in red grapes and some other plants. It has been suggested to have anti-inflammatory and anticancer properties, partly through the induction of IRF-1 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a component of turmeric, exhibits anti-inflammatory and antioxidant effects. It has been reported to induce IRF-1 expression, potentially contributing to its immunomodulatory properties. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol found in green tea known for its antioxidant and anticancer properties. It has been shown to induce IRF-1 expression in certain cell types. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid found in various fruits and vegetables. It possesses anti-inflammatory and immune-modulating effects and has been associated with the upregulation of IRF-1 expression. | ||||||