IRF-1 Antibody (E-4): sc-514544

IRF-1 Antibody (E-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects IRF-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IRF-1 (E-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Interferon regulatory factor-1 (IRF-1) plays a crucial role in the immune response by acting as a transcriptional activator for type I interferon genes, which are essential for antiviral defense and immune regulation. IRF-1 is primarily located in the nucleus, where IRF-1 binds to specific DNA sequences in the promoters of interferon-α and interferon-β genes, facilitating their transcription. This nuclear localization enables direct regulatory effects on gene expression, thereby influencing the immune response to infections and other stimuli. Additionally, IRF-1 interacts with other members of the interferon regulatory factor family, such as IRF-2, which can modulate IRF-1 activity, highlighting the complexity of the regulatory networks involved in immune responses. IRF-1′s ability to activate transcription while being antagonized by IRF-2 underscores IRF-1′s importance in maintaining a balanced immune response, making IRF-1 a significant target for research in immunology and therapeutic interventions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IRF-1 Antibody (E-4) has 19 citations in a variety of scientific publications.

Primary antibodies like Anti-IRF-1 Antibody (E-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IRF-1 Antibody (E-4) Specifications

Alternate Product Name: IRF-1

Product Clone Name: E-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 307-328

Epitope Target: IRF-1

Epitope Species: mouse

Product Reactivity/Detection: IRF-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 19 citations in various scientific publications

Available Conjugates/Forms for IRF-1 Antibody (E-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin, X: TransCruz Reagent

The preferred IRF-1 antibody is IRF-1 Antibody (H-8): sc-74530.