Gα s Inhibitors
Common Gα s Inhibitors include, but are not limited to SQ 22536 CAS 17318-31-9, NF449 CAS 627034-85-9, NF 023 CAS 104869-31-0, Nobiletin CAS 478-01-3 and MRS 1754 CAS 264622-58-4.
Gαs inhibitors are a class of chemical compounds specifically designed to target and inhibit the function of the Gαs protein, a crucial component of the heterotrimeric G protein complex involved in signal transduction. Gαs, or the G alpha subunit of the stimulatory G protein, plays a pivotal role in mediating cellular responses to extracellular signals, particularly those transmitted through G protein-coupled receptors (GPCRs). Upon activation by a GPCR, Gαs exchanges GDP for GTP and dissociates from the Gβγ subunits, subsequently activating adenylyl cyclase. This activation leads to the conversion of ATP to cyclic AMP (cAMP), a key secondary messenger that regulates numerous cellular processes, including metabolism, gene expression, and cell growth. By inhibiting Gαs, researchers can block the production of cAMP, effectively disrupting the downstream signaling pathways that rely on this molecule.
In research, Gαs inhibitors are valuable tools for dissecting the complex signaling networks mediated by GPCRs and for understanding the specific contributions of Gαs to various cellular functions. By blocking Gαs activity, scientists can explore how the inhibition affects cAMP levels and the subsequent impact on cellular processes such as energy metabolism, hormone regulation, and ion channel activity. These inhibitors allow researchers to investigate the dynamics of G protein signaling, including the interactions between Gαs and its associated receptors, effectors, and regulatory proteins. Additionally, Gαs inhibitors provide insights into the role of Gαs in physiological and pathological conditions where altered cAMP signaling plays a significant role. Through these studies, the use of Gαs inhibitors enhances our understanding of the molecular mechanisms underlying GPCR signaling, the regulation of secondary messengers like cAMP, and the broader implications of G protein function in cellular communication and homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $93.00 $356.00 | 13 | |
SQ 22536 is an adenylate cyclase inhibitor that indirectly affects Gαs. It inhibits cAMP production by blocking adenylate cyclase activity, leading to reduced Gαs-mediated cAMP signaling and downstream effects. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $199.00 $460.00 $1479.00 | 1 | |
NF449 is an adenosine receptor antagonist that can inhibit Gαs signaling. It interferes with adenosine receptor-Gαs coupling, resulting in reduced Gαs-mediated cAMP signaling and downstream cellular responses. | ||||||
NF 023 | 104869-31-0 | sc-204124 sc-204124A | 10 mg 50 mg | $158.00 $617.00 | 1 | |
NF023 is a non-selective purinergic receptor antagonist that has been suggested to inhibit Gαs signaling by interfering with purinergic receptor-Gαs coupling, leading to reduced Gαs-mediated cAMP signaling. | ||||||
Nobiletin | 478-01-3 | sc-202733 | 10 mg | $189.00 | 2 | |
Nobiletin is a natural compound that has been proposed to inhibit Gαs signaling and cAMP production. It may interact with Gαs or downstream components in the Gαs-cAMP pathway, leading to reduced cAMP levels and cellular effects. | ||||||
MRS 1754 | 264622-58-4 | sc-301174 sc-301174A | 5 mg 25 mg | $210.00 $818.00 | 1 | |
MRS 1754 is a selective antagonist of the P2Y6 receptor that indirectly affects Gαs. By blocking P2Y6 receptor-Gαs coupling, it reduces Gαs-mediated cAMP signaling and downstream cellular responses. | ||||||
NF 157 | 104869-26-3 | sc-204125 sc-204125A | 1 mg 5 mg | $490.00 $2000.00 | 1 | |
NF157 is a non-selective purinergic receptor antagonist that has been suggested to inhibit Gαs signaling. It interferes with purinergic receptor-Gαs coupling, leading to reduced Gαs-mediated cAMP signaling. | ||||||
YM 254890 | 568580-02-9 | sc-507356 | 1 mg | $500.00 | ||
YM-254890 is a Gq/11 protein inhibitor that indirectly affects Gαs. It reduces the activity of Gq/11, which can have cross-talk effects on Gαs signaling, leading to altered cellular responses dependent on Gαs-mediated pathways. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
W-7 is a calmodulin inhibitor that may affect Gαs signaling indirectly. By inhibiting calmodulin, it can modulate the activity of downstream effectors that interact with Gαs, leading to altered Gαs-mediated signaling and cellular responses. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a calcium channel blocker that may impact Gαs signaling indirectly. By reducing intracellular calcium levels, it can modulate downstream effectors involved in Gαs-mediated signaling pathways and cellular responses. | ||||||
SC 19220 | 19395-87-0 | sc-203450B sc-203450C sc-203450 sc-203450A | 1 mg 5 mg 10 mg 50 mg | $22.00 $104.00 $184.00 $797.00 | 2 | |
SC 19220 is an inhibitor of adenylyl cyclase that indirectly affects Gαs. By inhibiting adenylyl cyclase, it reduces cAMP production downstream of Gαs, leading to altered cellular responses dependent on Gαs-mediated cAMP signaling. | ||||||