Gα s Activators
Common Gα s Activators include, but are not limited to Forskolin CAS 66575-29-9, PGE2 CAS 363-24-6, Serotonin hydrochloride CAS 153-98-0, Dimaprit dihydrochloride CAS 23256-33-9 and CGS 21680 Hydrochloride CAS 124431-80-7.
Gα s activators represent a distinct chemical class renowned for their capacity to modulate the activity of the G protein alpha subunit stimulatory (Gα s ), a critical component of the G protein-coupled receptor (GPCR) signaling pathway. These activators function by influencing the interactions and pathways involving Gα s, which is integral to transmitting extracellular signals from cell surface receptors to intracellular effectors. Gα s mediates diverse cellular responses, including the activation of adenylyl cyclase and subsequent cyclic AMP (cAMP) production, leading to the activation of downstream signaling cascades. Gα s activators are thoughtfully designed to target specific mechanisms or pathways associated with Gα s, thereby influencing its cellular functions and downstream effects.
The development of Gα s activators entails a comprehensive understanding of the structural attributes of Gα s and its interactions with GPCRs, adenylyl cyclase, and other effector molecules. Researchers in this field work to engineer molecules that promote the activation of Gα s, contributing to its role in transducing signals from receptors to intracellular effectors. These activators often employ innovative design strategies that enhance Gα s 's functional role in amplifying cellular responses through cAMP-mediated pathways. By gaining insights into the intricate mechanisms through which Gα s participates in modulating various physiological processes, researchers aim to unravel its significance in fundamental cellular phenomena. Ongoing advancements in molecular pharmacology and chemical synthesis drive the refinement of Gα s activators, offering applications across diverse scientific domains where manipulation of Gα s -mediated processes is of interest.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is known to activate adenylate cyclase, leading to increased cAMP levels, which can stimulate Gαs-coupled receptor signaling indirectly. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic receptor agonist that activates Gαs-coupled receptors, leading to increased cAMP production and downstream signaling. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 can activate certain Gαs-coupled receptors, resulting in increased cAMP levels and downstream effects on Gαs-mediated signaling pathways. | ||||||
Serotonin hydrochloride | 153-98-0 | sc-201146 sc-201146A | 100 mg 1 g | $118.00 $187.00 | 15 | |
Serotonin HCl, which is also known as 5-hydroxytryptamine hydrochloride (5-HT HCl), is a neurotransmitter and vasoconstrictor that primarily acts on serotonin receptors. It can activate various subtypes of serotonin receptors, depending on the specific receptor subtype and tissue context. | ||||||
Dimaprit dihydrochloride | 23256-33-9 | sc-201090 | 100 mg | $218.00 | ||
Dimaprit dihydrochloride is a synthetic histamine analog that specifically targets histamine H2 receptors. When it binds to histamine H2 receptors, it triggers a signaling cascade that involves the activation of Gαs. The activation of Gαs leads to the stimulation of adenylate cyclase, an enzyme that converts ATP to cyclic AMP (cAMP). | ||||||
CGS 21680 Hydrochloride | 124431-80-7 | sc-211062 sc-211062A | 10 mg 50 mg | $292.00 $1044.00 | 7 | |
CGS 21680 is a synthetic compound that specifically targets the adenosine A2A receptor, which is a G protein-coupled receptor (GPCR) coupled to the Gαs protein. When CGS 21680 binds to the adenosine A2A receptor, it triggers a signaling cascade that involves the activation of Gαs. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $94.00 $141.00 | ||
Salbutamol is a selective β2-adrenergic receptor agonist. It binds to and activates β2-adrenergic receptors, which are G protein-coupled receptors (GPCRs) that are coupled to the Gαs protein. When Salbutamol binds to these receptors, it triggers a signaling cascade that involves the activation of Gαs. | ||||||