Dimaprit dihydrochloride CAS: 23256-33-9
MF: C6H15N3S•2HCl
MW: 234.19
A specific agonist of the histamine H2-receptor.

Dimaprit dihydrochloride (CAS 23256-33-9)

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Alternate Names: S-(3-Dimethylaminopropyl)isothiourea . 2HCl
Application: Dimaprit dihydrochloride is a specific agonist of the histamine H2-receptor
CAS Number: 23256-33-9
Molecular Weight: 234.19
Molecular Formula: C6H15N3S•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Dimaprit has been shown to be a highly specific histamine H2-receptor agonist. When administered in vitro, it has been shown to relax guinea pig parenchymal strips and tracheal spirals that had been constricted by the H1 receptor agonist, 2-PEA, or by carbachol. Dimaprit·2HCl is an inhibitor of NOS1.


References

1. Tenner, T.E. 1981. Pharmacology. 22: 227-234. PMID: 6455672
2. Hill, S.J., et al. 1990. Pharmacol. Rev. 42: 45-83. PMID: 2164693
3. Drazen, J.M., et al. 1979. Eur. J. Pharmacol. 55: 233-239. PMID: 156641
4. Netti, C., et al. 1984. Pharmacology. 28: 262-267. PMID: 6233621
5. Parsons, M.E., et al. 1994. Agents Actions. 43: 132-138. PMID: 7725964

Physical State :
Solid
Solubility :
Soluble in water (25 mg/mL).
Storage :
Store at room temperature
Melting Point :
159-161° C
IC50 :
nNOS: IC50 = 49 µM
pK Values :
pKb: 8.23, 9.23
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UM3850000
PubChem CID :
90045
MDL Number :
MFCD00069260
Beilstein Registry :
5982506
SMILES :
CN(C)CCCSC(=N)N.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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