Molecular structure of Dimaprit dihydrochloride, CAS Number: 23256-33-9
Dimaprit dihydrochloride (CAS 23256-33-9)
Alternate Names:
S-(3-Dimethylaminopropyl)isothiourea . 2HCl
Application:
Dimaprit dihydrochloride is a specific agonist of the histamine H2-receptor
CAS Number:
23256-33-9
Molecular Weight:
234.19
Molecular Formula:
C6H15N3S•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Dimaprit dihydrochloride is an analogue of the neurotransmitter acetylcholine and acts as an agonist of the muscarinic acetylcholine receptors. It may act to be a highly specific histamine H2-receptor agonist. When administered in vitro, it may act to relax guinea pig parenchymal strips and tracheal spirals that had been constricted by the H1 receptor agonist, 2-PEA, or by carbachol. Dimaprit dihydrochloride is also an inhibitor of NOS1. It has antispasmodic, anti-inflammatory, anticonvulsant, and neuroprotective properties, as well as the ability to modulate the activity of enzymes and receptors.
Dimaprit dihydrochloride (CAS 23256-33-9) References
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- Antinociceptive effect of centrally administered cimetidine and dimaprit in the rat. | Netti, C., et al. 1984. Pharmacology. 28: 262-7. PMID: 6233621
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- Comparison of H2 receptor agonists in rabbit atria and aorta. | Tenner, TE. 1981. Pharmacology. 22: 227-34. PMID: 6455672
- Characterization of neuronal and vascular histamine receptors mediating the salivary and vasodilator responses to histamine of the dog submandibular gland. | Shimizu, T., et al. 1981. Tohoku J Exp Med. 134: 1-8. PMID: 6458925
- Dimaprit--[S-[3-(N,N-dimethylamino)propyl]isothiourea]--a highly specific histamine H2-receptor agonist. Part 1. Pharmacology. 1977. | Parsons, ME., et al. 1994. Agents Actions. 43: 132-8. PMID: 7725964
- Pituitary-adrenocortical responsiveness to histaminergic stimulation during social stress of crowding in rats. | Gadek-Michalska, A., et al. 1994. Agents Actions. 41 Spec No: C80-1. PMID: 7976812
Inhibitor of:
NOS1.Activator of:
A cyclase (Adenylate cyclase), Gα s, and Histamine H2 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dimaprit dihydrochloride, 100 mg | sc-201090 | 100 mg | $218.00 |