IPP Activators
Chemical activators of the inositol polyphosphate phosphatase (IPP) operate through several distinct biochemical pathways. Many, such as LY294002 and Wortmannin, are inhibitors of phosphatidylinositol 3-kinase (PI3K). Inhibition of PI3K leads to a decrease in AKT activation, reducing its inhibitory influence on IPP and thereby indirectly increasing the activation of IPP. Other compounds, including Okadaic Acid and Calyculin A, operate through inhibition of protein phosphatases 1 (PP1) and 2A (PP2A), which can enhance the phosphorylation and activation of IPP.
Several compounds, including Forskolin, Isoproterenol, 8-bromo-cAMP, Epinephrine, IBMX, and Rolipram, function through the cAMP-dependent protein kinase A (PKA) pathway. These compounds increase cAMP levels, leading to PKA activation, which can then phosphorylate and activate IPP. Another set of compounds, Ionomycin and A23187, are calcium ionophores that increase intracellular calcium levels. Increased calcium levels can activate calmodulin, a calcium-binding protein, which can bind to and activate IPP. Thus, the chemical activators of IPP exert their effects through a variety of biochemical pathways, reflecting the diversity of regulatory inputs that control the activity of this enzyme.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. Inhibition of PI3K can lead to decreased activation of AKT, preventing its inhibitory influence on IPP. This can lead to an increase in the activation of IPP. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent PI3K inhibitor. By inhibiting PI3K, AKT activation is decreased, preventing its inhibitory action on IPP. This can lead to an increased activation of IPP. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatase 2A (PP2A). By inhibiting PP2A, Okadaic Acid can increase the phosphorylation and activation of IPP. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
Calyculin A is a potent PP1 and PP2A inhibitor. Inhibition of these phosphatases can increase the phosphorylation and activation of IPP. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an activator of adenylyl cyclase, which increases cAMP levels. Elevated cAMP can activate PKA, which can phosphorylate and activate IPP. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a β-adrenergic receptor agonist, leading to increased cAMP levels. Increased cAMP can activate PKA, which then promotes IPP phosphorylation and activation. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-bromo-cAMP is a cell-permeable cAMP analog. By increasing cAMP levels, 8-bromo-cAMP can activate PKA which in turn phosphorylates and activates IPP. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine is an adrenergic receptor agonist. Binding of epinephrine to its receptors activates adenylyl cyclase, increasing cAMP levels. This leads to PKA activation, which can phosphorylate and activate IPP. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor which increases intracellular cAMP, activating PKA. Activated PKA can phosphorylate and activate IPP. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective PDE4 inhibitor, leading to increased cAMP levels. This activates PKA, which can phosphorylate and activate IPP. | ||||||